holoprosencephaly/hypoxia

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Extramedullary hematopoiesis within a frontoethmoidal encephalocele in a newborn with holoprosencephaly.

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We present the first report of extramedullary hematopoiesis (EMH) in an encephalocele. The patient was a new-born with semilobar holoprosencephaly, a frontoethmoidal encephalocele, and a large subdural hematoma. The encephalocele appeared as a hemorrhagic mass, protruding from the forehead to cover

Cyclopia, aprosencephaly, and acardiac twinning: Is hypoxia-ischemia a unifying mechanism?

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In a recent case of monochorionic diamniotic twinning we observed one twin with acardia, cyclopia, and aprosencephaly, an association not reported previously. In most cases of acardia, the development of tissues in superior regions of the body is disrupted severely, while inferior structures develop

Central nervous system in twin reversed arterial perfusion sequence with special reference to examination of the brain in acardius anceps.

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The twin-reversed arterial perfusion (TRAP) sequence, or acardia, is the most severe complication in monozygotic twinning. Although more than 400 cases with TRAP sequence were reported since 1533, thorough investigations of the brain in those cases with a rudimentary head remained infrequent. We

Middle interhemispheric fusion.

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We report a case of a 19-year-old woman with seizures and mental deficiency attributed to perinatal anoxia. Brain MR showed a congenital malformation, a rare form of semilobar holoprosencephaly termed middle interhemispheric fusion.

Prenatal craniofacial development: new insights on normal and abnormal mechanisms.

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Technical advances are radically altering our concepts of normal prenatal craniofacial development. These include concepts of germ layer formation, the establishment of the initial head plan in the neural plate, and the manner in which head segmentation is controlled by regulatory (homeobox) gene

Prenatal craniofacial development: new insights on normal and abnormal mechanisms.

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Animal models for human craniofacial malformations.

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Holoprosencephaly malformations, of which the fetal alcohol syndrome appears to be a mild form, can result from medial anterior neural plate deficiencies as demonstrated in an ethanol treated animal model. These malformations are associated with more medial positioning of the nasal placodes and

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