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8 rezultatus
A role for 5alpha-reductase activity in the development of male homosexuality?
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Higher body hair with lower mesmorphism ratings were observed in Caucasian homosexual men compared with the general male population, reflecting elevated 5alpha-reductase (5alphaR) activity, and higher dihydrotestosterone-to-testosterone (DHT-to-T) ratio, in sharp contrast to 46,XY 5alphaR 2
5alpha-reductase 2 inhibition impairs brain defeminization of male rats: reproductive aspects.
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The present study was carried out to determine whether 5alpha-reductase 2 (5alpha-R2) metabolic pathway plays a key role in brain sexual differentiation. The inhibition of 5alpha-R2 by finasteride (20 mg/kg/day) from gestational day 19 to postnatal day 5 has long-term effects on sexual behavior and
Relapse Pneumocystis carinii pneumonitis and adverse reaction to current therapy in patients with AIDS: trimetrexate as an alternative.
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This is a case report of a 31-yr-old homosexual male with AIDS, admitted to our clinic with a relapse P. carinii pneumonitis (PCP) and a previous history of severe adverse reactions to currently used therapy. He was treated successfully with trimetrexate (TMTX), a dihydrofolate reductase inhibitor
Methaemoglobinaemia due to amyl nitrite inhalation: a case report.
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Methaemoglobinaemia is a potential toxic effect of aliphatic nitrites which are increasingly abused by male homosexuals and drug addicts because of marked vasodilating properties ('poppers'). In most instances, severe complications were described following the ingestion of large quantities of amyl,
Hypothalamic digoxin, hemispheric dominance and the acquired immunodeficiency syndrome.
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OBJECTIVE
Hypothalamic digoxin, an isoprenoidal metabolite, is an endogenous regulator of membrane Na(+)-K(+) ATPase activity, immune activation and synaptic neurotransmission. The objective of this study was to assess the role of hypothalamic digoxin and hemispheric dominance in the pathogenesis of
Childhood Abuse Experiences and the COMT and MTHFR Genetic Variants Associated With Male Sexual Orientation in the Han Chinese Populations: A Case-Control Study.
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BACKGROUND
Although it is widely acknowledged that genetic and environmental factors are involved in the development of male homosexuality, the causes are not fully understood.
OBJECTIVE
To explore the association and interaction of childhood abuse experiences and genetic variants of the
Etiology of homosexuality.
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The range of expression of homosexuality and its association with certain cultural, environmental, and genetic factors are most consistent with the concept of a multifactorial trait. Additionally, genetic heterogeneity in this phenotype (alternative mutants corresponding to a single phenotype) is
Sexual activity influences organ weight and androgen metabolism of rat prostate, bulbocavernosus/levator ani muscle and kidney.
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Previously we have shown that rats living under heterosexual conditions (HE-rats) have significantly higher weights of androgen target organs like prostate and bulbocavernosus/levator ani muscle (BCLA) than rats living under homosexual conditions (HO-rats). Knowing that androgen metabolism is an
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