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hypogonadism/phosphatase

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Puslapis 1 nuo 69 rezultatus
OBJECTIVE The aim of this preliminary study was to determine the possible relationship between alkaline phosphatase (ALP) levels in the gingival crevicular fluid (GCF) and periodontal disease in men with hypergonadotropic hypogonadism (HH). METHODS A total of 41 patients were divided into four

The effect of hypogonadism and testosterone-enhancing therapy on alkaline phosphatase and bone mineral density.

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OBJECTIVE To evaluate the relationship of testosterone-enhancing therapy on alkaline phosphatase (AP) in relation to bone mineral density (BMD) in hypogonadal men. METHODS Retrospective review of 140 men with testosterone levels of <350 ng/dL undergoing testosterone-enhancing therapy and followed

On the mark? Is alkaline phosphatase a surrogate for bone density in men with hypogonadism?

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OBJECTIVE Studies that analyze the levels of osteoprotegerin (OPG) or receptor activator of nuclear factor kappa B ligand (RANKL) in hypogonadal men, the majority of whom have prostate cancer or are undergoing androgen-deprivation therapy, are few and inconclusive. METHODS 81 men aged 69.3 ± 0.8

Factors of mineral homeostasis impairment and bone mineral density loss in women with central hypogonadism

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Objective: The aims of the study were to estimate markers of mineral turnover and bone mineral density (BMD) in young women with central hypogonadism (CH) in comparison with healthy young and postmenopausal women, and to reveal the possible impact of different factors on BMD.Method: We

Male Hypogonadism Causes Obesity Associated with Impairment of Hepatic Gluconeogenesis in Mice.

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The steroid hormones synthesized by the male gonads play diverse roles in biological processes. Androgens, the primary hormones produced by the male gonads, are key regulators of fat homeostasis, hence androgen-deprivation therapies often induce obesity. However, the molecular mechanism by which

Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover.

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Isolated hypogonadotropic hypogonadism (IHH) presents with delayed puberty in the late teens or early twenties, with a period of testosterone deficiency during active growth. The aims of the study were to determine 1) whether long term treatment of IHH results in normalization of bone density (BMD)

Bone loss following hypogonadism in men with prostate cancer treated with GnRH analogs.

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It is known that bone mineral density (BMD) is low in men who are hypogonadal. However, the rate and sites of bone loss following testosterone deficiency are not known. The resulting hypogonadism after GnRH analog therapy for the treatment of prostate cancer allows us to examine bone loss and bone

Spurious testosterone laboratory results in a patient taking synthetic alkaline phosphatase (asfotase alfa).

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OBJECTIVE We report a case of discordant total and free testosterone values in a patient with hypogonadism and juvenile hypophosphatasia after he initiated treatment with asfotase alfa, recombinant tissue non-specific alkaline phosphatase. METHODS Total testosterone was evaluated using immunoassay

Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.

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Acquired hypogonadism is being increasingly recognized in adult men. However, the effects of long term testosterone replacement on bone density and body composition are largely unknown. We investigated 36 adult men with acquired hypogonadism (age, 22-69 yr; median, 58 yr), including 29 men with

Hip fracture in elderly men: the importance of subclinical vitamin D deficiency and hypogonadism.

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OBJECTIVE To determine the major risk factors for hip fracture in elderly men. METHODS Prospective recruitment, followed by analysis of clinical and biochemical variables. METHODS Men aged 60 years and older who presented to St George Hospital (a 650-bed tertiary-care centre) in 1995, comprising all

Bone loss in young women with primary hypogonadism and its prevention with calcitonin.

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A total of 63 healthy young women with primary amenorrhea, 37 control women at the same age with normal ovarian function and 118 postmenopausal women underwent bone mineral density (BMD) measurements at the lumbar spine (L2-L4) by dual photon absorptiometry. Mean +/- SE BMD value in the primary

Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats.

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Rutin, a food derived-polyphenolic bioflavonoid, has been acknowledged for several health benefits. This study aims to explore the ameliorative effects of rutin against carbon tetrachloride (CCl4) toxicity in male rats. Adult male rats were given either CCl4 (30% in olive oil,

Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor.

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Early studies demonstrated that whole-body androgen receptor (AR)-knockout mice with hypogonadism exhibit insulin resistance. However, details about the mechanisms underlying how androgen/AR signaling regulates insulin sensitivity in individual organs remain unclear. We therefore generated hepatic
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