intermittent claudication/viduriavimas

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Effects of policosanol and ticlopidine in patients with intermittent claudication: a double-blinded pilot comparative study.

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Policosanol is a cholesterol-lowering drug with concomitant antiplatelet effects. The present study was undertaken to compare the effects of policosanol and ticlopidine in patients with moderately severe intermittent claudication (IC). The study had a 4-week baseline step, followed by a 20-week

Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease.

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OBJECTIVE This study evaluated the effects of cilostazol on walking distances in patients with intermittent claudication (IC) caused by peripheral arterial occlusive disease. METHODS The study was a multicenter, randomized, double-blind, placebo-controlled trial. Two hundred thirty-nine patients

[Cilostazol is effective and safe option for the treatment of intermittent claudication. Results of the NOCLAUD study].

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Intermittent claudication can seriously impair the patients' quality of life. Cilostazol was registered in Hungary in 2014. This study aimed to evaluate the efficacy and safety of cilostazol in patients with intermittent claudication. 1405 patients were enrolled to the 6 months, multicenter,

A comparison of cilostazol and pentoxifylline for treating intermittent claudication.

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OBJECTIVE We performed a randomized, double-blind, placebo-controlled, multicenter trial to evaluate the relative efficacy and safety of cilostazol and pentoxifylline. METHODS We enrolled patients with moderate-to-severe claudication from 54 outpatient vascular clinics, including sites at Air Force,

Cilostazol: treatment of intermittent claudication.

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OBJECTIVE To review the pharmacology and clinical utility of cilostazol, an antiplatelet and vasodilator agent approved for the management of intermittent claudication. METHODS Primary literature on cilostazol was identified from a comprehensive MEDLINE literature search (1980-February 2000).

A new pharmacological treatment for intermittent claudication: results of a randomized, multicenter trial.

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BACKGROUND Effective medication is limited for the relief of intermittent claudication, a common manifestation of arterial occlusive disease. Cilostazol is a potent inhibitor of platelet aggregation with vasodilation effects. OBJECTIVE To evaluate the safety and efficacy of cilostazol for the

Cilostazol: a review of its use in intermittent claudication.

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Cilostazol (Pletal) is a selective inhibitor of phosphodiesterase-III with antiplatelet, antithrombotic and vasodilating properties. It also exhibits antiproliferative effects on smooth muscle cells and has beneficial effects on high density lipoprotein-cholesterol and triglyceride

Cilostazol Can Increase Skin Oxygen Supply Assessed by Transcutaneous Oxygen Pressure Measurement in Type 2 Diabetes With Lower Limb Ischemic Disease: A Randomized Trial.

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OBJECTIVE The purpose of this study was to compare the efficacy and safety of cilostazol versus acetylsalicylic acid (ASA) for amelioration of lower limb ischemia in type 2 diabetes. METHODS Prospective, randomized positive-controlled open clinical trial. METHODS Eighty-nine patients with type 2

The coral reef aorta - a single centre experience in 70 patients.

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Coral reef aorta (CRA) is described as rock-hard calcifications in the visceral part of the aorta. These heavily calcified plaques grow into the lumen and can cause significant stenoses, which may lead to malperfusion of the lower limbs, visceral ischemia or hypertension due to renal ischemia. From

Case report: Pentoxifylline treatment in microscopic colitis.

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BACKGROUND Microscopic colitis is a common cause of diarrhea. Pentoxifylline, a xanthine derivative with anti-tumor necrosis factor-alpha properties, is prescribed for intermittent claudication and other disorders. Our goal was to evaluate the outcomes of patients with microscopic colitis treated

Analysis of the cilostazol safety database.

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Cilostazol, a type III phosphodiesterase inhibitor, was approved in the United States in 1999 for the reduction of the symptoms of intermittent claudication. This article summarizes the safety data from 8 cilostazol phase 3 controlled clinical trials, involving 2,702 patients: 1,374 receiving

Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake.

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Cilostazol (Pletal), a quinolinone derivative, has been approved in the U.S. for the treatment of symptoms of intermittent claudication (IC) since 1999 and for related indications since 1988 in Japan and other Asian countries. The vasodilatory and antiplatelet actions of cilostazol are due mainly to

Garlic: empiricism or science?

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Garlic (Allium sativum L. fam. Alliaceae) is one of the best-researched, best-selling herbal remedies and is also commonly used as a food and a spice. Garlic constituents include enzymes (for example, alliinase) and sulfur-containing compounds, including alliin, and compounds produced enzymatically

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