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l asparaginase/sarkoma
Nuoroda įrašoma į mainų sritį
Puslapis 1 nuo 21 rezultatus
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
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OBJECTIVE
To evaluate the activity of the antitumor enzyme L: -asparaginase (ASNase) on tumor cells of mesenchymal origin and the contribution of glutamine synthetase (GS) to the adaptation to the metabolic stress caused by the anti-tumor enzyme.
METHODS
We studied the effects of ASNase in six human
Acute myeloid leukemia with mediastinal myeloid sarcoma refractory to acute myeloid leukemia therapy but responsive to L-asparaginase.
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We report the case of a 14-year-old female with acute myeloid leukemia (AML) and myeloid sarcomas (MS) in the anterior mediastinum and around numerous bones. Laboratory tests showed a white blood cell count of 4.0 × 10(9)/l with 7.0 % blasts. Computed tomography revealed a mediastinal mass and
[Case of reticulum cell sarcoma treated with L-asparaginase and antibody to L-asparaginase].
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Effect of L-asparaginase from Aspergillus terreus on ascites sarcoma in the rat.
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Inhibitory activity of L-asparaginase from Mycobacterium tuberculosis on Yoshida ascites sarcoma in rats.
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Studies on inhibition of viral oncogenesis. II. Inhibitory effect of L-asparaginase, clam liver extract and methotrexate on rous sarcoma virus focus formation.
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[The quantative measurement of cytocidal actions of antimetabolites, Vinca alcaloids and L-asparaginase against in vitro cultured Yoshida ascites sarcoma cells].
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Inhibition of Rd/3 rat sarcoma by L-asparaginase alone and in combination with sodium para-amino-salicylate.
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Comparison of antitumor effect of recombinant L-asparaginase with wild type one in vitro and in vivo.
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OBJECTIVE
To investigate the antitumor effect of recombinant L-asparaginase on the growth of several tumors such as P388, L1210, hepatocellular carcinoma (Heps), K562, P815, and sarcoma 180 (S180).
METHODS
Tumor cells (K562, L1210, and P815) were cultured in vitro and the morphology of those cells
[Complete remission achieved by L-asparaginase, vincristine and prednisolone (LVP) therapy in secondary leukemia (M5a type) with an MLL gene rearrangement].
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A 16-year-old boy was operated upon for synovial sarcoma of the right thigh and underwent chemotherapy consisted of adriamycin (320 mg), cisplatin (780 mg), etoposide (4,200 mg) and ifosfamide (30,000 mg). He developed secondary leukemia 18 months after the chemotherapy. Acute lymphoblastic leukemia
Interaction of antitumor agents including doxorubicin or daunorubicin in sarcoma-180 system.
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Combination effect of antitumor agents, including doxorubicin and daunorubicin, was evaluated on the concept of pharmacological synergism in ascites sarcoma-180 system. In alternate adminsitration, combinations of doxorubicin plus cyclophosphamide, thio-TEPA, carboquone, actinomycin-D, vinblastine,
Thromboembolism in children with cancer: a retrospective multicenter study in Korea.
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Thromboembolism (TE) is a major cause of morbidity and mortality in adult cancer patients; however, there is a lack of sufficient knowledge on TE in pediatric cancer patients. We aimed to determine the epidemiology of TE in Korean children with cancer. Between January 2000 and July 2015, we
Thrombocytopenia associated with neoplasia in dogs.
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Ten percent (214/2,059) of all dogs with cancer at North Carolina State University Veterinary Teaching Hospital had thrombocytopenia. The thrombocytopenia was associated with infectious/inflammatory etiologies in 4%, miscellaneous disorders (therapy, bone marrow failure, disseminated intravascular
Phase I dose escalating study of oral cyclophosphamide in tumour-bearing cats
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Cyclophosphamide is an alkylating agent used to treat cats with lymphoma, carcinomas and sarcomas. However, no clear consensus exists regarding the maximum tolerated dose (MTD) of oral cyclophosphamide in cats. Toxicities are rarely reported at published oral dosages of cyclophosphamide (200-300
Biological modifiers and their role in cancer therapy.
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Biological modification in cancer therapy involves many different strategies and substances. Bacterial products with established usefulness include BCG, C. parvum and L-Asparaginase. Immunotherapy with such agents has not, however, found general application, although revived interest in 'Coley's
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