One drop of Cacicol20 will be applied 4-6 hours after the surgery, in one of the randomly chosen eye, and thereafter one drop daily until the reepithelialization is completed.

One drop of conservative free artificial tear (Oculac, Thea Laboratories) will be applied to one eye at the same time when Cacicol20 is instilled to the other eye.

Corneal Erosion

Cacicol20 is supplied as a sterile single-dose solution of alpha 1-6 poly-carboxymethyl glucose sulfate One drop is instilled at each application to impregnate cornea.

Cacicol20

Ocluac is artificial tear which contains Hydroxypropylmethyl Cellulose and Sodium Chloride, It is presented in a 0.4 mL vial. One drop is delivered at each application.

Placebo

Facilitation of Corneal Re-epithelialization After Photorefractive Keratectomy

Treatment of Postoperative Discomfort/Pain and Facilitation of Corneal Reepithelialization After Photorefractive Keratectomy

The patients will be examined daily the changes of reepithelialization area, until the re-epithelialization is complete. The days that takes for complete reepithelialization will be recorded.

Patient´s subjective evaluation of ocular symptoms including pain, burning, stinging, tearing, and photophobia in the two eyes, with score ranging from 0-5 (0 representing absence of symptom and 5 representing unbearable symptom) will be performed daily

Epithelial thickness in the central 2 mm and mid-peripheral (2-5 mm) cornea will be measured in µm using anterior segment spectrum-domain optical coherence tomography

Concentration of inflammatory cytokines in tears including interleukin 1ß (IL-1ß), IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-1RA (receptor antagonist), eotaxin, basic fibroblast growth factor (bFGF/FGF2), granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interferon gamma (IFN-γ), interferon gamma-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1α (MIP-1α/CCL3), MIP-1B, platelet-derived growth factor bb (PDGF-BB), regulated-on-activation normal T cell expressed and secreted (RANTES), tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) will be measured using Multiplex analysis

Uncorrected visual acuity will be measured using Snellen visual acuity chart

Subjective manifest refraction will be performed and spherical equivalent (SE) will be recorded in diopters

The proteome of tear fluid will be examined through Liquid chromatographymass spectrometry (LC-MS)

The incidence of postoperative complications (infection, haze formation, delayed epithelial healing) will be recorded in percentage

Clinical dry eye tests including ocular surface disease index (OSDI) questionnaire (score between 0-100, whith higher values presenting more severe dry eye symptoms), tear break-up time (recorded in seconds), ocular surface staining recorded using Oxford scale (0-15, with higher value representing more ocular surface staining), which will be used to determine the dry eye severity level, according to the 2007 Dry Eye Workshop (DEWS) report

Aleksandar Stojanovic

Medical Director

SynsLaser Kirurgi AS

Laboratoires Thea

Non-Randomized: Monoinfected Sofosbuvir/Velpatasvir/Voxilaprevir SOF/VEL/VOX days 0-7 Paired liver biopsy at days 0 and 7. SOF/VEL days 8 (week 2) through 84 (week 12). Post-treatment follow up through week 12.

Randomized: HIV/HCV coinfected; Sofosbuvir/Velpatasvir/Voxilaprevir SOF/VEL/VOX days 0 through 7, Paired liver biopsy days 0 and 7. SOF/VEL days 8 (week 2) through 84 (week 12). Post-treatment follow up through week 12.

Random Assignment of arm: Co-infection Sofosbuvir/Velpatasvir (SOF/VEL) days 0 through 7 and Paired liver biopsy days 0 and 7. SOF/VEL on day 8 (week 2) through 84 (week 12) . Post-Treatment follow up through week 12

HCV Coinfection

Liver Disease

Sofosbuvir/Velpatasvir/Voxilaprevir [SOF/VEL/VOX]

Sofosbuvir/Velpatasvir (SOF/VEL)

Johns Hopkins Hospital : The John G. Bartlett Specialty Practice

deLIVER: Direct Acting Antiviral Effects on the Liver

One week after treatment with direct-acting antivirals, the decline in intrahepatic and intracellular HCV RNA will be greater in patients treated with an non-structural 3 (NS3) protease inhibitor in combination with inhibitors of NS5A and NS5B compared to those treated with the latter two inhibitors alone.
2.2 One week after treatment with direct-acting antivirals, the decline in intrahepatic and intracellular HCV RNA quantity will be greater in persons with HCV compared to those with HIV/HCV coinfection.

plasma HCV RNA levels will be assessed by Real-Time Polymerase Chain Reaction (PCR) reported as international units (IU) per milliliter of blood

ISGs are interferon stimulated genes and will be measured in hepatocytes from the liver biopsy

ISGs are interferon stimulated genes and will be measured in non-parenchymal cells in the liver tissue obtained from the liver biopsy

HCV RNA levels in individual hepatocytes will be assessed by Real-Time Polymerase Chain Reaction (PCR) reported as international units per hepatocyte

Johns Hopkins University

Clopidogrel tablets 75 mg for six months:

Locally Advanced Pancreatic Cancer

Adenocarcinoma, Pancreas

Metastatic Pancreatic Cancer

Clopidogrel tablets 75 mg for six months:
In case of treatment with aspirin < or = 75 mg/d or prophylactic LMWH --> clopidogrel 75 mg/d If aspirin = 0 + LMWH = 0 --> clopidogrel 150 mg/d x 7days then 75mg/d

Clopidogrel

Placebo tablets 75 mg for six months:
In case of treatment with aspirin < or = 75 mg/d or prophylactic LMWH --> placebo 75 mg/d If aspirin = 0 + LMWH = 0 --> placebo 150 mg/d x 7days then 75mg/d

Service d'oncologie digestive - Institut Sainte Catherine

Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy

A Phase III Multi-centre Double-blind Placebo Controlled Study Analysing the Efficacy and Safety of Daily Administration of a P2Y12 Inhibitor (Clopidogrel) for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Diagnosis of pulmonary embolism (PE), deep venous thrombosis (DVT) and visceral vein event.

Overall survival is defined as time from randomization to death from any cause

All suspected bleedings will be classified as major, minor, clinically relevant non-major or no bleeding

Assistance Publique - Hôpitaux de Paris

Groupe Francophone Thrombose et Cancer

Adhesive dopped with Zn Oxide + Cu nanoparticles in a ( 5% / 0.2% concentration )

Caries, Dental

Np of OZn nanoparticles mixed with dental adhesive

Metal nanoparticles ( O Zn and Cu)

Dental Adhesive with commercial preparation

Dental Adhesive pure

Eduardo Fernández G

Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives

Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives on Their Antimicrobial Properties and Dentinal Matrix Metalloproteinases Activity: From Molecular Basis to Clinical Trials

UFC (Colony Forming Units) of Stretococus Mutans Count (Numbers) , Microtensile bond strength (Mpa)

To Assess Matrix Metallopeptidase 2 , 8 and 9 activity by in vitro test and ex vivo (Luminicense units compared vs controls of fluorecence) ( dentin powder obtained fron teeth donated)

Eduardo Fernandez

Profesor Titular

University of Chile

Split mouth, 2 premolars restored with 2 dental adhesives , 1 experimental and 1 control

Bottles with a label remarked with 2 letters A and B , same aspect

laser/protease

Facilitation of Corneal Re-epithelialization After Photorefractive Keratectomy

deLIVER: Direct Acting Antiviral Effects on the Liver

Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy

Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives

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