leukoaraiosis/phosphatase

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StraipsniaiKlinikiniai tyrimaiPatentai

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Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis.

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OBJECTIVE To investigate vessel density changes with increasing age in three areas of the brain and to correlate these changes with leukoaraiosis (LA) on the basis of magnetic resonance (MR) images and location in deep white matter (WM). METHODS Internal review board approval or informed consent

Periventricular venous collagenosis: association with leukoaraiosis.

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OBJECTIVE To investigate the association between an age-related degenerative disease of subependymal veins and leukoaraiosis. METHODS Brains obtained at autopsy from 22 patients (average age, 73.2 years; range, 25-95 years) were examined with magnetic resonance (MR) imaging and neuropathologic

Cerebral microvascular alterations in aging, leukoaraiosis, and Alzheimer's disease.

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We have been using alkaline phosphatase (AP) histochemical staining, formerly a research tool for the study of cerebral cortical vascular morphology, to examine pathological changes in the cortex and deep cerebral structures. Deep structures stain similarly to the cortex. The AP stain is found in

Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well.

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We investigated capillary density in 12 subjects with leukoaraiosis (LA), in 9 age-matched normal subjects, in 7 cases of Alzheimer's disease (AD), and 4 after whole-brain irradiation for brain tumors. In the LA study (which as been published), autopsy brains were evaluated by MRI. The presence of

Morphometric analysis of arteriolar tortuosity in human cerebral white matter of preterm, young, and aged subjects.

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Arteriolar tortuousities, consisting of vascular coils, loops, and spirals, appear in white matter in a subset of human cerebral vessels. Computerized morphometry was used to analyze brain sections from a broad age range of subjects to determine whether tortuosity is a phenomenon of aging or is

Microvascular changes in the white mater in dementia.

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Our studies of the brain microvascular system have focused on some aspects not commonly studied by other research groups because we use some techniques not often used by others. Our observations tend to add new details to the pathological picture rather than contradict the mainstream findings. We

Review: cerebral microvascular pathology in ageing and neurodegeneration.

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This review of age-related brain microvascular pathologies focuses on topics studied by this laboratory, including anatomy of the blood supply, tortuous vessels, venous collagenosis, capillary remnants, vascular density and microembolic brain injury. Our studies feature thick sections, large blocks

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