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Potential anti-tumor-promoting activity of 3alpha-hydroxy-D:A-friedooleanan-2-one from the stem bark of Mallotus philippensis.

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Four known friedelane-type triterpenoids, friedelin ( 1), 3-hydroxy-D:A-friedoolean-3-en-2-one ( 2), 2beta-hydroxy-D:A-friedooleanan-3-one ( 3), and 3alpha-hydroxy-D:A-friedooleanan-2-one ( 4), and two known lupane-type triterpenoids, lupeol ( 5) and betulin ( 6), were isolated from the stem bark of

Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1

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Anoctamin1 (ANO1), a calcium-activated chloride channel, is frequently overexpressed in several cancers, including human prostate cancer and oral squamous cell carcinomas. ANO1 plays a critical role in tumor growth and maintenance of these cancers. In this study, we have isolated two new compounds

Cytotoxic and antitumor constituents in pericarps of Mallotus japonicus.

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A variety of phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus were assessed for growth inhibiting activity against human larynx (HEp-2) and lung (PC-13) carcinoma cells as well as mouse B16 melanoma, leukemia P388, and L5178Y cells. Most of these derivatives were proved

Antitumor-promoting activity of mallotojaponin, a major constituent of pericarps of Mallotus japonicus.

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Mallotojaponin, a major constituent of the pericarps of Mallotus japonicus (Euphorbiaceae), inhibited the action of tumor promoter in vitro and in vivo; it inhibited tumor promoter-enhanced phospholipid metabolism in cultured cells, and also suppressed the promoting effect of

Enantiomeric chromene derivatives with anticancer effects from Mallotus apelta

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Mallotusapelta(Lour.) Müll.Arg has been used in traditional medicine for the treatment of chronic hepatitis. Six new chromene derivatives, malloapeltas C-H (1-6) and one known compound, malloapelta B (7) were isolated and structured from the leaves of M.apelta. Two pairs of enantiomers (1a/1b and

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines.

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It is widely accepted that apoptosis is closely associated with cancer cell death. However, whether autophagy induces tumor cell death has not been fully elucidated. Various studies have discussed the antitumor properties of rottlerin in human malignancies. The current study aimed to investigate the

Bergenin: a computationally proven promising scaffold for novel galectin-3 inhibitors.

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Bergenin is a C-glycoside of 4-O-methylgallic acid that is isolated from medicinal plants such as Flueggea leucopyrus, Bergenia crassifolia, Mallotus philippensis, Corylopsis spicata, Caesalpinia digyna, Mallotus japonicus, and Sacoglottis gabonensis. Even though there appears to be ample evidence

A review of the biological activity and chemistry of Mallotus japonicus (Euphorbiaceae).

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Biological and pharmacological activities of Mallotus japonicus (Euphorbiaceae) are reviewed. Chemical constituents, biological and pharmacological activities of tannins and related compounds, cardenolides, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, and inhibition

[Constituents of the pericarps of Mallotus japonicus (Euphorbiaceae)].

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Rottlerin-like phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus Muell. Arg. (Euphorbiaceae) are reviewed. Chemical structures, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, anti-HIV-RT activity, and inhibitory activity of activated

Inhibition of tumor-promoter-enhanced 3H-choline incorporation into cellular phospholipids by phloroglucinol derivatives from Mallotus japonicus.

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The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin, markedly inhibited the incorporation of 3H-choline into phospholipids of

A new chromone from the twig of Mallotus apelta.

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A new chromone, 7-hydroxy-2-hydroxymethyl-8-methoxy-4-oxo-4H-chromene-6-carboxylic acid, named melachromone, along with 13 known compounds (2-14), including chromones, flavonoids, coumarins and phenylpropane derivatives, were isolated from the twig of Mallotus apelta. Their chemical structures were

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