Subjects who received a single dose of MultiHance and no other Gd agent and who are also scheduled for orthopedic surgery

Subjects who received multiple doses of MultiHance and no other Gd agent and who are also scheduled for orthopedic surgery

Subjects who received a single dose of ProHance and no other Gd agent and who are also scheduled for orthopedic surgery

Subjects who received multiple doses of ProHance and no other Gd agent and who are also scheduled for orthopedic surgery

Subjects who have not received any Gd agent and who are also scheduled for orthopedic surgery

Gadolinium Retention

hip, shoulder or knee replacement surgery, limb amputations or other orthopedic surgical procedures

Surgery

VA San Diego Healthcare System

Evaluation of Gd Retention in Human Bone and Skin After MultiHance or ProHance Administration Compared With Control

A Prospective Multicenter Cohort Study Evaluating the Long Term Retention of Gadolinium in Human Bone and Skin After the Retrospective Administration of MultiHance or ProHance in Comparison With a Control Group Receiving No Exposure to Gadolinium

Determine the long-term gadolinium deposition in bone tissue and skin in subjects undergoing orthopedic surgery using Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) in nmol gadolinium/g from surgically removed bone and skin.

Bracco Diagnostics, Inc

Fluid Overload

Water Electrolyte Imbalance

Acid Base Imbalance

2 litres intravenous infusion in 60 minutes

Crystalloid

1 litre intravenous infusion over 30 minutes

Colloid

Brain and Body MRI Centre, University of Nottingham

The Effect of Crystalloids and Colloids on Visceral Blood Flow

The Effects of Balanced and Unbalanced Crystalloids and Colloids on Serum Biochemistry and Visceral Blood Flow: A Two Phase, Double Blind, Randomised Crossover Study

nephrogenic fibrosing dermopathy/kalis

Evaluation of Gd Retention in Human Bone and Skin After MultiHance or ProHance Administration Compared With Control

The Effect of Crystalloids and Colloids on Visceral Blood Flow

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