otitis externa/creatinine

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Absence of toxicity in patients with malignant otitis externa following long-term treatment with high dosage tobramycin.

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An in-vitro model of aminoglycoside dosing was used to demonstrate that the bactericidal activity of tobramycin against Pseudomonas aeruginosa is directly related to the peak concentration of the drug. In addition, six patients who were being treated for malignant otitis externa with long-term, high

Necrotizing external otitis: aminoglycoside and beta-lactam antibiotic treatment combined with surgical treatment.

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Necrotizing external otitis is a life-threatening condition that still causes therapeutic problems. A retrospective analysis of 22 patients who were all treated with a short standard course of aminoglycoside and beta-lactam antibiotic with through local debridement was carried out; 50% (11/22) had

Cefoperazone for empiric therapy in patients with impaired renal function.

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Thirty-five patients with serious infections and impaired renal function were treated empirically with 2 to 8 g of cefoperazone per day. Infections included sepsis in 14, nonbacteremic urinary infections in nine, pneumonia in five, intra-abdominal infection in five, fasciitis in one, and malignant

Successful orthotopic liver transplantation after trimethoprim-sulfamethoxazole associated fulminant liver failure.

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Trimethoprim-sulfamethoxazole (TMP-SMZ) is one of the most commonly used antibiotics. Although many of its adverse effects are well recognized, TMP-SMZ related hepatotoxicity is considered rare and is usually characterized by cholestasis or mixed hepatocellular-holestatic reactions. In this study,

Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability.

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Ciprofloxacin is a broad spectrum fluoroquinolone antibacterial agent. Since its introduction in the 1980s, most Gram-negative bacteria have remained highly susceptible to this agent in vitro; Gram-positive bacteria are generally susceptible or moderately susceptible. Ciprofloxacin attains

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