penile neoplasms/tyrosine

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StraipsniaiKlinikiniai tyrimaiPatentai

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EGFR mutational status in penile cancer.

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OBJECTIVE No substantial improvement in overall survival has been obtained over the past two decades in penile cancer (PC). Clinical data are available on the role of epidermal growth factor receptors (EGFR) inhibitors in PC but no EGFR mutational analysis has been conducted. METHODS We reviewed

Risk factors and molecular characterization of penile cancer: impact on prognosis and potential targets for systemic therapy.

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To provide a comprehensive summary of risk factors, molecular machinery as well as potential therapeutic targets with a particular focus on literature published in the last 2 years on prognosis and treatment of penile cancer (PeCa).E2F, LAMC2, MAML2, ID1

[Value of targeted therapy for penile cancer].

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With an incidence of 0.1-0.9/100,000 men/year, penile cancer is a rare cancer of the urogenital tract in Western Europe. At the time of initial diagnosis up to 45% of the patients already demonstrate metastatic disease and need some type of systemic treatment. Objective remission rates and 3-year

An update on systemic therapy for penile cancer.

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Whereas substantial advances have been made in systemic tumour therapy in the past decade, the prognosis of advanced squamous cell carcinoma (SCC) of the penis remains disproportionally poor. In this review, we aimed to present an update on systemic therapy of penile SCC highlighting

Understanding genomics and the immune environment of penile cancer to improve therapy

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The incidence of penile squamous cell carcinoma (PSCC) has increased in developed countries over the past decades owing to increased human papilloma virus (HPV) exposure. Despite successful surgical treatment of locoregional PSCC, effective treatment options for advanced disease are limited. The

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