phyllanthoside/vėžys

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Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

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Fifty-eight cell lines in the National Cancer Institute drug screen were analyzed for their ability to efflux the fluorescent dye rhodamine 123 as a functional assay for P-glycoprotein (Pgp). Using flow cytometry, the rhodamine fluorescence was measured for each cell line under four incubation

Disposition and metabolism of the antitumor glycoside phyllanthoside in mouse and beagle dog.

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Phyllanthoside is a naturally occurring glycoside with activity against IP transplantable murine tumors. Phyllanthoside administered IV, to mice at a nontoxic dose of 16 mg/kg could not be detected in blood or plasma even 30 s after administration. There was rapid formation of a less polar

Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic.

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The development of anticancer agents has, in the past, relied heavily on leads derived from screening a wide variety of agents from both synthetic and natural sources. With the development of new techniques of measurement of biochemical changes in cells and the advent of molecular biological

Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents

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Twenty-four novel organometallic osmium(II) phenylazopyridine (AZPY) complexes have been synthesised and characterised; [Os(η⁶-arene)(5-RO-AZPY)X]Y, where arene = p-cym or bip, AZPY is functionalized with an alkoxyl (O-R, R = Me, Et, ⁿPr, ⁱPr, ⁿBu) or

Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles.

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The National Cancer Institute (NCI) Human Tumor Cell Line Anti-Cancer Drug Screen has evaluated the cytotoxicity profiles of a large number of synthetic compounds, natural products, and plant extracts on 60 different cell lines. The data for each compound/extract can be assessed for similarity of

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