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Nuoroda įrašoma į mainų sritį
4 rezultatus
[Towards cure for all children with acute lymphoblastic leukemia?].
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Prisijungti Registracija
Childhood acute lymphoblastic leukemia is a model in oncology. The outcome was dismal 40 years ago but is now generally excellent, owing to the recent advent of new drugs. These advances were made possible by the creation of specialized units, better supportive care (transfusions, antibiotics and
The Role of the Central Nervous System Microenvironment in Pediatric Acute Lymphoblastic Leukemia.
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Prisijungti Registracija
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. While survival rates for ALL have improved, central nervous system (CNS) relapse remains a significant cause of treatment failure and treatment-related morbidity. Accordingly, there is a need to identify more efficacious and
Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all.
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Prisijungti Registracija
The application of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has revolutionized the treatment of acute promyelocytic leukemia (APL). More than 80-90% of patients are expected to be cured with a combination of ATRA, ATO and/or chemotherapy. In this review, we focus on the remaining
The role of pharmacokinetic and pharmacodynamic studies in the planning of protocols for the treatment of childhood cancer.
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Prisijungti Registracija
The chemosensitive nature of many childhood cancers means that chemotherapy has a greater role in therapy than in adult practice. However, the present methods, schedules of administration and combinations have often been derived form historical precedent rather than from pharmacological knowledge.
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