7 rezultatus
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is filed under the provisions of 35 U.S.C. .sctn.371 and claims the priority of International Patent Application No. PCT/EP2007/053900 filed on 20 Apr. 2007 entitled "Synthesis and Uses of Pyroglutamic Acid Derivatives" in the name of Julio
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims priority under 35 U.S.C. .sctn.119(a) of European Patent Application No. 06380090.8 for "Synthesis and Uses of Pyroglutamic Acid Derivatives," filed on Apr. 20, 2006 in the name of Julio lvarez Builla Gomez et al., which is incorporated
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to compounds which inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4.
2. References
The following publications, patents and patent applications are cited in this application as superscript
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to compounds which inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4.
References
The following publications, patents and patent applications are cited in this application as superscript
FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
Not applicable.
BACKGROUND OF THE INVENTION
Ribonucleases such as ribonuclease A ("RNase A") and their cytotoxicity towards tumor cells were discovered in the 1960s (reviewed in Roth, J., Cancer Res. 23:657 666 (1963)). In the 1970s, human serum was also
The present application is based on Japanese Patent Application No. 2002-177774, Japanese Patent Application filed Apr. 7, 2003, and Japanese Patent Application No. 2003-131997, the entire contents of which are incorporated herein by reference.
BACKGROUND OF THE INVENTION
1. Field of the
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a national phase application based on the PCT International Patent Application No. PCT/JP2014/065879 filed Jun. 16, 2014, claiming priority to Japanese Patent Application No. 2013-136178 filed Jun. 28, 2013, the entire contents of both of which are