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Puslapis 1 nuo 17 rezultatus
[Rotenoids from Derris trifoliata].
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Five rotenoids named dehydrodeguelin, dehydrorotenone, 12a-hydroxy rotenone, tephrosin and 12alphabeta-hydroxyrot-2'-enonic acid were isolated from aerial parts of Derris trifoliata. All these compounds were isolated from this plant for the first time.
7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.
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From the acetone extract of the roots of Derris trifoliata an isoflavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isoflavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known
Rotenoid derivatives from Derris trifoliata with nitric oxide production inhibitory activity.
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Study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) collected in Singapore led to the isolation and identification of three known and two new rotenoid derivatives. The new derivatives, named derrisfolin A (1) and B (2), inhibited nitric oxide production in murine
Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata.
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The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named
Anti-Angiogenic Activity of Rotenoids from the Stems of Derris trifoliata.
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The plants in the genus Derris have proven to be a rich source of rotenoids, of which cytotoxic effect against cancer cells seem to be pronounced. However, their effect on angiogenesis playing a crucial role in both cancer growth and metastasis has been seldom investigated. This study aimed at
Review article number 135 biosynthesis in the rotenoid group of natural products: applications of isotope methodology.
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Using the natural rotenoids rotenone, amorphigenin, deguelin, rotenonic acid, dalpanol and munduserone as examples, their phytochemical biosynthesis has been examined in Derris elliptica, Amorpha fruticosa and Tephrosia vogelii. The rotenoids are advanced isoflavonoids, and construction of their
Novel N-containing rotenoid and seco-rotenoid from the root of Derris elliptica.
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Two new rotenoids, 2-hydroxy-5-aminorotenonone (1) and elliptoic acid (2), were isolated from the roots of Derris elliptica collected in Guangdong Province, China. Their structures were established by extensive spectral analysis. Compound 1 is the first N-containing rotenoid and compound 2 is the
[Modification of the analytical method for rotenoids in plants].
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Rotenoids are the active ingredients of some botanical insecticides and prospective candidates as anticancer agents. The proper isolation and determination of rotenoids in plants is of great importance for their further research and development. However, the HPLC method available for this purpose
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
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A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
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A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents
Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents.
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A new rotenoid, derrisin (1), together with 10 known rotenoids (2-11) were isolated from the roots of Derris malaccensis Plain. The structure of 1 was elucidated by spectroscopic analysis. Nine of the isolated rotenoids (3-11) showed antibacterial activity against Helicobacter pylori.
[Separation and preparation of two rotenoids from the roots of Derris by high-speed counter-current chromatography].
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Two rotenoids (rotenone and deguelin) were successfully isolated and purified from the roots of Derris by high-speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of n-hexane-ethylacetate-methanol-water (7: 0. 25:5:3, v/v/v/v) on a preparative scale. The lower phase
Analysis and quantitation of rotenoids and flavonoids in Derris (Lonchocarpus urucu) by high-temperature high-resolution gas chromatography.
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A glass capillary column coated with PS-086 (15% phenyl-80% methylpolysiloxane, 15 m x 0.30-mm i.d., 0.1-microm film thickness) is used to analyze extracts from Lonchocarpus urucu (Derris urucu). Several secondary metabolites (8 flavonoids, 10 rotenoids) are characterized without derivatization, and
Two new flavonoids from the seeds of Derris scandens.
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Two new flavonoids, (2S)-3',4',5'-trimethoxyflavanone (1) and 2'-hydroxy-2,4-dimethoxy-4'-O-[(E)-3,7-dimethyl-2,6-octadienyl]chalcone (2), together with a known pterocarpene, flemichapparin B (3), and a known rotenoid, dehydrodeguelin (4), were isolated from the seeds of Derris scandens. Their
Preparative isolation, fast centrifugal partition chromatography purification and biological activity of cajaflavanone from Derris ferruginea stems.
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BACKGROUND
The Derris genus is known to contain flavonoid derivatives, including prenylated flavanones and isoflavonoids such as rotenoids, which are generally associated with significant biological activity.
OBJECTIVE
To develop an efficient preparative isolation procedure for bioactive
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