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Hemoglobin Sabine [beta 91 (F7) Leu-->Pro]: occurrence in a Sardinian individual with hemolytic anemia and inclusion bodies.

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BACKGROUND Hemoglobin (Hb) Sabine (beta 91 Leu-->Pro) is an unstable variant detected for the first time in a 16-year-old Scottish-English-German girl affected by moderately severe hemolytic anemia. A second case was described in a patient of Yugoslavian descent. We report another case of this Hb

Unstable hemoglobin hemolytic anemia: in vitro incubation studies on erythrocytes with hemoglobin Sabine.

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Familial hemolytic anemia due to Hb Sabine [beta 91(F7)Leu-->Pro] identified by polymerase chain reaction.

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Hemoglobin sabine beta 91 (f 7) leu to pro. An unstable variant causing severe anemia with inclusion bodies.

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Severe hemolytic anemia due to combined α thalassemia and de novo Hemoglobin Sabine.

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Severe central nervous system thrombotic events in hemoglobin Sabine patient.

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Hemoglobin (Hb) Sabine is a rare, unstable Hb variant resulting from the point mutation in codon 91 (CTG --> CCG) of beta-globin gene. We report a case of Hb Sabine patient with mild hemolytic anemia, unusually high Hb F level and severe central nervous system thrombotic disturbances. We have tried

Analysis of erythrocyte membrane proteins in patients with hereditary spherocytosis and other types of haemolytic anaemia.

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OBJECTIVE In order to investigate the pathophysiology of erythrocyte membrane proteins, 10 patients (6 pre- and 4 post-splenectomy) with hereditary spherocytosis (HS) and other patients with haemolytic anaemia were examined. METHODS The membrane proteins were analysed by biochemical and mass

Unstable Hemoglobin Variants: The Need for Clinical Vigilance in Infants with Congenital Jaundice.

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Unstable hemoglobin (Hb) variants are a rare etiology of congenital jaundice caused by hemolytic anemia. For infant patients with jaundice this disorder is often under diagnosed or the last consideration. We report a 14-month-old boy, who presented with a long-standing jaundice. His diagnosis of Hb

THE VIRUS OF INFECTIOUS FELINE AGRANULOCYTOSIS : I. CHARACTERS OF THE VIRUS: PATHOGENICITY.

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Thirty-two strains of an infectious filterable agent, with properties that establish it as a virus, have been isolated from a malady of cats. This disease can be readily recognized and differentiated from other feline diseases by blood studies, which make apparent the characteristic profound

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