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sandoricum indicum/priešvėžiniai vaistai
Nuoroda įrašoma į mainų sritį
5 rezultatus
Ichthyotoxic and anticarcinogenic effects of triterpenoids from Sandoricum koetjape bark.
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After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with
Plant anticancer agents, L. cytotoxic triterpenes from Sandoricum koetjape stems.
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A new ring-A secotriterpene, koetjapic acid [1], and five known compounds, 3-oxo-olean-12-en-29-oic acid [2] (a novel natural product), katonic acid [3], (-)-alloaromadendrene, (-)-caryophyllene oxide, and (+)-spathulenol, have been isolated and characterized from a cytotoxic Et2O-soluble extract of
Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells.
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Deregulated cell signaling pathways result in cancer development. More than one signal transduction pathway is involved in colorectal cancer pathogenesis and progression. Koetjapic acid (KA) is a naturally occurring seco-A-ring oleanene triterpene isolated from the Sandoricum koetjape stem bark. We
Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats
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Purpose: Koetjapic acid is an active compound of a traditional medicinal plant, Sandoricum koetjape. Although koetjapic acid has a promising anticancer potential, yet it is highly insoluble in aqueous solutions. To increase aqueous
Increased aqueous solubility and proapoptotic activity of potassium koetjapate against human colorectal cancer cells.
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OBJECTIVE
Recently, we have isolated koetjapic acid (KA) from Sandoricum koetjape and identified its selective anticancer potentiality against colorectal carcinoma. KA is quite likely to be useful as a systemic anticancer agent against colorectal malignancy. However, with extremely low solubility,
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