securinine/flueggea suffruticosa

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Flueggeacosines A-C, Dimeric Securinine-Type Alkaloid Analogues with Neuronal Differentiation Activity from Flueggea suffruticosa.

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Flueggeacosines A-C (1-3), three dimeric securinine-type alkaloid analogues with unprecedented skeletons, were isolated from Flueggea suffruticosa. Compounds 1 and 2 are the first examples of C-3-C-15' connected dimeric securinine-type alkaloids. Compound 3 is an unprecedented heterodimer of

[Cultivation experiments of securinega suffruticosa Rehd. as securinine source. IV].

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[Cultivation experiments of Securinega suffruticosa Rehd, as securinine source. II].

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[Cultivation experiments of Securinega suffruticosa Rehd, as securinine source. 3].

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[STUDIES ON SECURININE. II. ISOLATION OF DIHYDROSECURININE FROM SECURINEGA SUFFRUTICOSA (PALL.) REHD].

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[Experiment on cultivation of Securinega suffruticosa Rehd., the source of securinine. 1].

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[STUDIES ON THE EXTRACTION AND ISOLATION OF SECURININE FROM SECURINEGA SUFFRUTICOSA (PALL.) REHD. BY ADSORPTION WITH ACTIVE CARBON].

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[Experiments on the cultivation of plants containing securinine in Izu, Japan. 1. Comparison of the growth of Securinega suffruticosa Rehder at sunny and shady places].

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L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation.

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L-securinine is a natural product extracted and isolated from the leaf of dried Securinega suffruticosa. The aim of the present study was to explore the effects of L-securinine on proliferation, and the methylation profile of the dickkopf-related protein 1 (DKK1) gene in human lung cancer cells and

Securinega suffruticosa.

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This review gives an account of the current knowledge on the chemical constituents, biological activity and pharmacological properties of Securinega suffruticosa. A wide range of chemical compounds have been isolated, mainly alkaloids, flavonoids, tannins and lipids. From the pharmacological point

Production of therapeutically relevant indolizidine alkaloids in Securinega suffruticosa in vitro shoots maintained in liquid culture systems.

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Microshoot cultures of the Chinese medicinal plant Securinega suffruticosa (Pall.) Rehd. were established and evaluated for the presence of therapeutically relevant indolizidine alkaloids securinine (S) and allosecurinine (AS). The cultures were maintained in shake flasks (SFs) and a bubble column

Securinine suppresses osteoclastogenesis and ameliorates inflammatory bone loss

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Securinine (Sec) is a naturally derived compound separated from the roots of Securinega suffruticosa, which has long been used as a herbal medicine. Sec is widely known as a GABA receptor antagonist, it is also known as an innate immune cell agonist and has been reported to increase macrophage

Development and validation of LC-MS/MS method for quantitative determination of (-)-securinine in mouse plasma.

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(-)-Securinine (SE) is a major alkaloid found in plant Securinega suffruticosa, which has a wide range of pharmacological activities including anticancer, anti-parasitic and central nervous system stimulating effects, etc. To aid the pharmacological study of SE, we developed an LC-MS/MS method for

Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells.

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Natural products have been discovered to be valuable sources of antitumor drugs. L-Securinine is a natural product extracted from the leaves or roots of Securinega suffruticosa Pall Rehd. The current study was done to investigate the molecular mechanisms of antitumor effects of L-securinine. The

Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth.

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Securinine, an alkaloid originally isolated from Securinega suffruticosa, exhibits a wide range of biological activities, including anti-malarial activity. Along with securinine, 10 pyrrolidine derivatives, generated via the retrosynthesis of (-)-securinine, were selected and tested for their

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