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securinine/leukemija
Nuoroda įrašoma į mainų sritį
4 rezultatus
Securinine induced apoptosis in human leukemia HL-60 cells.
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Prisijungti Registracija
OBJECTIVE
To study whether securinine might induce apoptosis in human leukemia HL-60 cells.
METHODS
Inhibition of proliferation was measured using MTT assay. The amount of apoptotic cells was measured by flow cytometry. DNA fragmentation was visualized by DNA agarose gel electrophoresis and the
L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway.
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Prisijungti Registracija
The Securinega alkaloids are a class of natural products isolated from plants of the Euphorbiaceae family. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 indicating its potential as an efficient natural antitumor drug with low toxicity. The aim of the present
Securinine, a myeloid differentiation agent with therapeutic potential for AML.
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Prisijungti Registracija
As the defining feature of Acute Myeloid Leukemia (AML) is a maturation arrest, a highly desirable therapeutic strategy is to induce leukemic cell maturation. This therapeutic strategy has the potential of avoiding the significant side effects that occur with the traditional AML therapeutics. We
The Securinega alkaloids.
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Prisijungti Registracija
Securinega alkaloids represent a family of plant secondary metabolites known for 50 years. Securinine (1), the most abundant and studied alkaloid of this series was isolated by Russian researchers in 1956. In the following years, French and Japanese scientists reported other Securinega compounds and
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