Neodymium-Doped Yttrium Aluminum Garnet (Nd-YAG) (Fotona XP®) laser is a successful therapeutic modality and is characterized by its safe profile compared to other lasers.
Short pulsed Nd-YAG laser (Fotona XP® Accelera mode) results in a non-ablative dermal heating with intact overlying epidermis which has shown a potential for dermal collagen remodeling in histological sections.

Carbon dioxide (CO2) (Deka SmartXide DOT®) laser is one of the well-tolerated therapeutic modalities used for treatment of different skin disorders including striae alba.
CO2 laser targets mainly water content in both epidermis and dermis causing vaporization of target cells.
Fractional ablative CO2 laser creates columns of focal dermo-epidermal tissue loss known as (microablative columns) with thermal damage, hemostatic effect and incomplete coagulation of tissues. This ablation of dermal tissues (including collagen and elastin) has the potential for stimulation of new tissue formation in striae distensae.

Striae Distensae

Striae; Albicantes

Striae Alba

Nd-YAG Laser

Fractional CO2 Laser

High Frequency Skin Ultrasound

Short Pulsed Nd-YAG

Carbon Dioxide Laser

Neodymium-Doped Yttrium Aluminum Garnet Laser

Application of four laser sessions one month apart using short pulsed mode of 1064 nm Nd-YAG laser (Fotona XP® - Accelera mode) using parameters (fluence 20-40 J/Cm2, pulse duration= 0.25 ms and spot size 3-5 mm) for one side.

Laser

Application of four laser sessions one month apart (in the same day after Nd-YAG session) using 10600 nm ablative fractional CO2 laser (Deka SmartXide DOT®) using -parameters (fluence 17-20 J/Cm2, pulse duration 700-1000 µs, spacing 600-700 µm and stacking 1-2) on the other. Sessions are separated by one month interval plus three months for clinical follow up.

Cairo University

Efficacy of Short Pulsed 1064 nm Nd-YAG Laser Versus 10600 nm Fractional CO2 Laser in Treatment of Striae Alba

Efficacy of Short Pulsed 1064 nm Nd-YAG Laser Versus 10600 nm Fractional CO2 Laser in Treatment of Striae Alba: A Randomized Clinical Trial

Assessment of the efficacy and therapeutic superiority of either 1064 nm Nd-YAG laser or 10600 nm fractional CO2 laser as treatment modalities for patients with striae alba guided by investigated dermal changes obtained by high frequency skin ultrasound machine, namely: dermal thickness, sub epidermal low echogenicity band thickness and epidermal thickness, both before and after treatment with both laser machines. Statistical analysis of outcome data shall be carried out to determine significance of efficacy of one laser modality over the other.

Treating and improving lesions of striae alba for all of the 25 patients included in the sample using short pulsed 1064 nm Nd-YAG laser and 10600 nm fractional CO2 laser each on one side of the area affected, for four successive sessions with one month interval. The degree of improvement shall be determined through comparing modified Davey's score both before and after treatment sessions.

Manal Bosseila

Professor of dermatology - cairo university

Written informed consent is to be obtained from each participant.
Detailed history taking including onset, course, duration of the disease and received medications.
Serial digital photography before and after each session and three months after sessions.
Clinical assessment to determine the severity of SD using modified Davey's visual score.
Comparable sides of striae are randomly allocated to one of the treatment modalities in a randomized table technique.
Application of four laser sessions one month apart using short pulsed mode of 1064 nm Nd-YAG laser (Fotona XP® Accelera mode) for one side and 10600 nm ablative fractional CO2 laser (Deka SmartXide DOT®) on the other. Sessions are separated by one month interval plus three months for clinical follow up.
Assessment using high frequency skin ultrasound before session, before 4th session and 3 months after last session.

Comparable sides of striae are randomly allocated to one of the treatment modalities in a randomized table technique.

Group receiving treatment with Venus Versa IPL energy

The Venus Versa system consists of a console and 4 detachable applicators that deliver optical energy in the form of Intense Pulsed Light to the patient skin. The intense pulsed light lamp delivers non-coherent light distributed over a range of wavelengths from 500 nm to 1200 nm. Different filters are embedded in the different applicators so that each applicator can deliver the desired spectrum according to the indications to be treated.In this study, the IPL applicator SR580 will be evaluated for the treatment of Striae Distensae, depending on the patient's skin type.

Venus Versa

water based gel used to protect the skin during light based treatments. Is also commonly used during ultrasound treatments.

IPL gel

Rosenberg Plastic Surgery

Clinical Evaluation of Using Intense Pulsed Light for Improving the Appearance of Striae Distensae

Clinical Evaluation of Venus Versa SR Applicator Using Intense Pulsed Light on Skin Texture for Improving the Appearance of Striae Distensae

Improvement in treated area appearance after the last treatment as determined by 3 blinded reviewers.

Subjects will be given a questionnaire to assess their satisfaction and tolerance to the treatments

striae distensae/edema

Efficacy of Short Pulsed 1064 nm Nd-YAG Laser Versus 10600 nm Fractional CO2 Laser in Treatment of Striae Alba

Clinical Evaluation of Using Intense Pulsed Light for Improving the Appearance of Striae Distensae

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