3 rezultatus
BACKGROUND OF THE INVENTION
The present invention relates to a method of reducing levels of TNF.alpha. and inhibiting phosphodiesterase in a mammal and to compounds and compositions useful therein.
TNF.alpha., or minor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear
This invention relates to the discovery that certain latent isocyanate derivatives are capable of irreversibly deactivating the proteolytic enzyme human leukocyte elastase (HLE). The inhibitors of this invention have been found to bond to primary specificity sites to thereby irreversibly eliminate
BACKGROUND OF THE INVENTION
The present invention relates generally to anti-inflammatory drugs and more particularly to novel compounds for inhibition of the cyclooxygenase activity of prostaglandin synthase, an essential enzyme in the prostaglandin synthesis pathway. Prostaglandins (PGs),