taxinine/taxus cuspidata

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A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.

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A new taxoid, 5alpha,13alpha-diacetoxy-10beta-cinnamoyloxy-4(20),11-taxadien-9alpha-ol (1) along with its 9,10-isomer, taxinine NN-11 (2) were isolated from the callus cultures of Taxus cuspidata. The structures were identified by the analyses of the spectral data and chemical method. Their in vitro

Four Novel Taxane Diterpenoids from the Needles of Japanese Yew, Taxus cuspidata.

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Four novel taxane diterpenes were isolated from the needles of the Japanese yew, Taxus cuspidata. Their structures were established as 1-hydroxy taxuspine C, 2α,7β,9α, 10β,13α-pentaacetoxy-5α-cinnamoyloxy-4β,20-epoxy- taxa-11-en-1β-ol, 2α,9α,10β,13α-tetraacetoxy-taxa-4(20), 11-dien-5α-ol and

Bioactive taxoids from the Japanese yew Taxus cuspidata.

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A series of new taxoids, named taxuspines A-H and J-Z (1-25) and taxezopidines A-H and J-L (26-36), have been isolated together with 37 known taxoids (37-73) including paclitaxel (53) from the Japanese yew, Taxus cuspidata Sieb. et Zucc. (Taxaceae). These new taxoids possess various skeletons

Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.

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Two taxoids, taxinine NN-7 (1) and 3,11-cyclotaxinine NN-2 (2), were isolated from the neutral fraction of the EtOAc extract of a mixture of needles and young stems of Taxus cuspidata. The structures were determined by spectroscopic analysis. Both compounds showed some activity as modulators of

[Studies on chemical constituents of the stem bark of Taxus cuspidata].

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In order to study the active constituents in the stem barks of Taxus cuspidata Sieb. et Zucc., led to the isolation and structural determination of three compounds. On the basis of chemical evidences and spectral analysis (UV, IR, 1HNMR, 13CNMR and FAB-MS,) the structures of I, II and III were

[Studies on chemical constituents in heartwood of Taxus cuspidata].

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OBJECTIVE To study the chemical constituents in the heartwood of Taxus cuspidata. METHODS Silica gel column chromatography, preparative HPLC and preparative TLC were used to isolate and purify the chemical constituents; 1H- and 13C-NMR spectroscopic methods were used for structural

Production of biologically active taxoids by a callus culture of Taxus cuspidata.

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Ten known taxoids, paclitaxel, 7-epi-taxol, taxol C, baccatin VI, taxayuntin C, taxuyunnanine C and its analogues (2-5), and yunnanxane (6), and an abietane, taxamairin A, were produced in the callus culture of Taxus cuspidata cultivated on a modified Gamborg's B5 medium in the presence of 0.5 mg/L

Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K.

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A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. BTK reversed the resistance to paclitaxel, doxorubicin

Multidrug resistance reversal activity of taxoids from Taxus cuspidata in KB-C2 and 2780AD cells.

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Some non-taxol-type taxoids having neither an oxetane ring at C-4 and C-5 nor an N-acylphenyl-isoserine group at C-13, such as taxuspine C, 2'-desacetoxyaustrospicatine, and 2-desacetoxytaxinine J, which were isolated from the Japanese yew Taxus cuspidata, increased cellular accu-mulation of

A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.

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Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing

Highly increased cellular accumulation of vincristine, a useful hydrophobic antitumor-drug, in multidrug-resistant solid cancer cells induced by a simply reduced taxinine.

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Regio- and/or chemo-selective reductions of taxinine (1a), a taxane diterpenoid readily obtainable from the needles of a Japanese yew (Taxus cuspidata), at the 5-O-cinnamoyl and 4-exo-methylene moieties have been accomplished by the catalytic hydrogenation over Pd/C or Rh/C to obtain

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