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4 rezultatus
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration.
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Prisijungti Registracija
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of chemotherapy drugs. Molecules that promote axonal
The acute effects of taxol upon regenerating axons after nerve crush.
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Prisijungti Registracija
The effects of taxol, a compound renowned for its ability to promote microtubule assembly, were studied upon axons after its injection into rat sciatic nerve immediately following a local nerve crush injury. The single injection of taxol was delivered into the lesion site and the animals were
Taxol-induced neuropathy: chronic effects of local injection.
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Prisijungti Registracija
The long-term neurotoxic effects of taxol, a compound known to promote microtubule protein polymerization, injected subepineurially into rat sciatic nerve were studied up to 10 weeks post-injection. At the site of injection, taxol caused local axonal reactions and degeneration which were causally
Taxol produces a predominantly sensory neuropathy.
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Prisijungti Registracija
Taxol, a plant alkaloid with promise as an antineoplastic agent, produced a predominantly sensory neuropathy in 16 of 60 patients treated in two phase I trials. This neuropathy occurred only at taxol doses greater than 200 mg/m2. Symptoms typically started 1 to 3 days following treatment, beginning
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