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5 rezultatus
Buprenorphine for cancer pain: is it ready for prime time?
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Prisijungti Registracija
Buprenorphine (BUP) is a semisynthetic derivative of the opium alkaloid thebaine found in the poppy Papaver somniferum. Its chemical structure contains the morphine structure but differs by having a cyclopropylmethyl group. Buprenorphine is a potent µ opioid agonist. Buprenorphine undergoes
Cell death-inducing activity of opiates in human oral tumor cell lines.
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In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells lines (HSC-2 and HSG). The cytotoxic activity of codeinone (CC50=1.0-1.2 microg/mL) against HSC-2 or HSG cells was higher than that of doxorubicin (CC50=1.9-2.0 microg/mL).
Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants.
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Alkaloids represent a large and diverse group of compounds that are related by the occurrence of a nitrogen atom within a heterocyclic backbone. Unlike other types of secondary metabolites, the various structural categories of alkaloids are unrelated in terms of biosynthesis and evolution. Although
Impact of buprenorphine on learning and memory ability, oxidative status and inflammation in the hippocampus of rat
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Background: Buprenorphine (BUP) a "synthetic derivative of the opioid alkaloid thebaine" may be associated with cellular damage in the central nervous system.
Aims: This study
Pharmacology of opioids in the treatment of chronic pain syndromes.
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The perpetual pursuit of pain elimination has been constant throughout human history and pervades human cultures. In some ways it is as old as medicine itself. Cultures throughout history have practiced the art of pain management through remedies such as oral ingestion of herbs or techniques
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