Patients with morbid obesity who were eligible for and willing to have bariatric surgery performed

Age and BMI matched patients with morbid obesity who either were not eligible for or were not willing to have bariatric surgery performed - no sufficient number of matched patients has completed the study; the arm of obese patients not treated with bariatric surgery has been discarded for the purpose of the analyses

Thyroid

Obesity

Insulin Resistance

Autoimmune Thyroiditis

patients who had received treatment with bariatric surgery for medical reasons

Bariatric surgery

Thyroid in Bariatric Surgery

Changes in Thyroid Function Tests and Texture Following Bariatric Surgery Induced Weight Loss

Measurement of thyroid ultrasound (grey scale assessment, volume, echogenicity) and thyroid function tests (free T4, free T3, TSH and rT3) at baseline and at least 3 months after surgery when relevant weight loss is achieved

Martin Weickert

Study Principal Investigator

University Hospitals Coventry and Warwickshire NHS Trust

Preoperative Galectin 3 dosage in plasma and water rinse of the needle aspiration biopsy

Goiter, Nodular

Preoperative Galectin 3 dosage in plasma and water rinse of the needle aspiration biopsy.

Galectin 3 dosage

Centre Henri Becquerel

CHRouen

Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter

Diagnosis Interest of Galectin 3 Dosage in Nodular and Multinodular Goiter Pretreatment

Se and Sp of plasmatic galectin 3 dosage will be established relative to the reference method which is the histological analysis of the specimen (report) asserting the existence of a vesicular lineage tumor, benign (adenoma) or malignant (papillary or follicular).
The threshold giving the best compromise for the values of Se and Sp will be searched graphically. Then the area under the curve and its confidence interval at 95% will be calculated and will be tested against the value 0.5, that is to say an area where the assay has no diagnostic value.

Se and Sp of galectin 3 dosage in the water rinse of the needle aspiration biopsy will be established relative to the reference method which is the histological analysis of the specimen (report) asserting the existence of a vesicular lineage tumor, benign (adenoma) or malignant (papillary or follicular).
The threshold giving the best compromise for the values of Se and Sp will be searched graphically. Then the area under the curve and its confidence interval at 95% will be calculated and will be tested against the value 0.5, that is to say an area where the assay has no diagnostic value.

thyroid nodule/carbohydrate

Thyroid in Bariatric Surgery

Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter

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