This group will perform a 6MWT with a sham-CPAP

Tracheobronchomalacia

Excessive Dynamic Airway Collapse

Use of a CPAP during a 6 minute walk test to maintain the airways open during the respiratory cycle

Continuous positive airway pressure (CPAP) device

An enlarged air leak incorporated into the exhalation valve will be positioned between the mask and the CPAP tubing, allowing airflow resistance of the exhalation port to be almost eliminated by increasing its area, thereby virtually cancelling positive pressure. Also an orifice restrictor in the CPAP circuit will be connected between the CPAP unit and the tubing in order to load the blower with the same airflow resistance as in true CPAP.

Sham-continuous positive airway pressure (CPAP) device

Beth Israel Deaconess Medical Center

Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC

Effect of Continuous Positive Airway Pressure (CPAP) on 6-Minute Walk Test Outcomes in Patients With Excessive Central Airway Collapse (ECAC)

Statistical difference between the 6 MWT results of the CPAP and sham-CPAP groups as compared with the initial results of the 6 MWT and between groups using ANCOVA.

Adnan Majid

This prospective, randomized placebo controlled, double-blind clinical trial will be conducted at Beth Israel Deaconess Medical Center (BIDMC) in accordance with Good Clinical Practice Standards and under IRB supervision. We plan to enroll a total of 32 patients with ECAC randomized by an opaque envelope technique into two different groups: group 1 (CPAP) and group 2 (sham-CPAP)
Group 1: This group will perform a 6MWT with CPAP
Group 2: This group will perform a 6MWT with a sham-CPAP

Randomization will be stratified using the variables sex (Female and male) and age (<60 and >60). Additionally a block 2-4 pattern will be used to assure a random and evenly distributed patient population in the different strata. Randomization will be carried out by the research coordinator; the rest of the personnel will be blinded to the allocation of the patients to the different groups.

10 patients with normal airways (no known airway diseases)

Airway biopsies and brushings are to be used for staining and culture, respectively

tracheobronchomalacia/lidocaine

Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC

Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis

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