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6 rezultatus
Whole brain quantitative CBF, CBV, and MTT measurements using MRI bolus tracking: implementation and application to data acquired from hyperacute stroke patients.
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Prisijungti Registracija
A robust whole brain magnetic resonance (MR) bolus tracking technique based on indicator dilution theory, which could quantitatively calculate cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) on a regional basis, was developed and tested. T2*-weighted gradient-echo
A novel SPECT-based approach reveals early mechanisms of central and peripheral inflammation after cerebral ischemia.
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Prisijungti Registracija
Inflammation that develops in the brain and peripheral organs after stroke contributes profoundly to poor outcome of patients. However, mechanisms through which inflammation impacts on brain injury and overall outcome are improperly understood, in part because the earliest inflammatory events after
Magnetic resonance imaging characteristics and surgical results of adrenocorticotropin-secreting pituitary adenomas.
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OBJECTIVE
To evaluate magnetic resonance imaging (MRI) characteristics and surgical results of adrenocorticotropin (ACTH)-secreting pituitary adenomas.
METHODS
MRI characteristics and relationship between MRI positive rate and surgical results of 266 patients with pathologically confirmed Cushing's
Bloodletting at Jing-well points decreases interstitial fluid flow in the thalamus of rats.
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OBJECTIVE
To investigate the changes in the neuronal microenvironment of the middle cerebral artery (MCA) territory induced by Jing-well points bloodletting acupuncture (WPBA) and to explore the neuroprotective mechanism of WPBA in stroke.
METHODS
Adult male Sprague Dawley (n = 32) rats were
The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder.
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Prisijungti Registracija
N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. KCNH3 is concentrated in the forebrain, and its
An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity.
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Prisijungti Registracija
Excitotoxicity, resulting from sustained activation of glutamate receptors of the N-methyl-d-aspartate (NMDA) subtype, is considered to play a causative role in the etiology of ischemic stroke and several neurodegenerative diseases. The NMDA receptor is therefore a target for the development of
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