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volkensin/neurodegenerative diseases
Nuoroda įrašoma į mainų sritį
4 rezultatus
Destruction of a sub-population of cortical neurones by suicide transport of volkensin, a lectin from Adenia volkensii.
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A method for the destruction of a sub-population of neocortical pyramidal neurones is described. The technique uses unilateral striatal injections of volkensin, a toxic lectin from Adenia volkensii, which undergoes retrograde axonal transport from the site of injection to destroy subcortically
Neuronal degeneration by suicide transport following injection of volkensin into rat cerebral cortex.
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We have examined the time course of neurodegeneration in subcortical nuclei and other cortical areas known to project to the rat parietal cortex, following unilateral injection of the suicide transport agent, volkensin, into the cortex of one side. Degenerating neurons, visualized by Gallyas silver
Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease.
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Retrogradely transported toxins are widely used to set up protocols for selective lesioning of the nervous system. These methods could be collectively named "molecular neurosurgery" because they are able to destroy specific types of neurons by using targeted neurotoxins. Lectins such as ricin,
Neuronal loss up-regulates clusterin mRNA in living neurons and glial cells in the rat brain.
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The aim of this study was to examine the time course and cellular localization of clusterin mRNA after neurodegeneration. Selective neuronal death was achieved in the rat inferior olivary complex after volkensin injection in the contralateral cerebellar cortex. Quantitative analysis of the in situ
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