vulvar neoplasms/tyrosine

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Treatment of squamous cell vulvar cancer with the anti-EGFR tyrosine kinase inhibitor Tarceva.

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BACKGROUND The purpose of this case report is to describe the first experience with erlotinib (Tarceva) in the treatment of locally advanced vulvar cancer. METHODS Two elderly patients presented with locally advanced vulvar cancer. Surgery was not a suitable method of treatment for either of them

Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells.

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A recent study reported on the efficacy of the EGFR inhibitor on locally advanced vulvar cancer. The aim of this study was to evaluate the effect of an EGFR tyrosine kinase inhibitor (AG1478) alone and in combination with cisplatin on vulvar cancer cells (A431 and SW962). We detected overexpression

[Use of free serum amino acids in therapy monitoring of patients with treated vulvar cancer].

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We investigated the value of 10 free serum amino acids in continuous therapy monitoring in 9 patients with primary cancer of vulva stag pT1-2pN0M0. In comparison with the normal we found elevated significantly asparginic acid, glutaminic acid, glycine, alanine, valine, isoleucine, leucie,

Extragastrointestinal stromal tumor originating from the vulva.

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. They have gain-of-function mutations of the c-kit receptor tyrosine kinase gene and have been suggested to originate from the interstitial cells of Cajal. A small percentage of GISTs form

Recent Advances in Identifying Biomarkers and High-Affinity Aptamers for Gynecologic Cancers Diagnosis and Therapy.

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Cancer is the uncontrollable abnormal division of cell growth, caused due to the varied reasons. Cancer can be expressed in any part of the body, and it is one of the death-causing diseases. Human reproductive organs are commonly damaged by cancer. In particular, the women reproductive system is

Major clinical research advances in gynecologic cancer in 2012.

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Ten topics were chosen among major clinical research achievements in gynecologic oncology in 2012. For ovarian cancer, comprehensive review of the history of bevacizumab studies was followed by poly adenosine diphosphate [ADP]-ribose polymerase (PARP) inhibitors and other molecular targeted agents

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