Brain's Response to Chocolate
Atslēgvārdi
Abstrakts
Apraksts
With obesity at an all-time high, understanding eating behavior beyond physical need is a priority. Food reinforcement is driven by central dopamine activity. However, objective measurement of brain dopamine-related behavioral events is hindered by the lack of non-invasive, accessible techniques that are amenable to testing in a "naturalistic" environment. The goal of this project is to develop a non-invasive, accessible methodology to measure dopaminergic responses to food in a natural setting. This research will use a novel, hand-held electroretinograph (ERG) that does not require eye dilation and uses a skin electrode to measure retinal dopamine activity. Previous work establishes that retinal dopamine activity can be used as a proxy for central dopamine function. The ability to assess both subjective behavioral variables and central dopaminergic responses simultaneously will provide an ideal approach for innovative studies of the control of eating behavior.
Datumi
| Pēdējoreiz pārbaudīts: | 06/30/2019 |
| Pirmais iesniegtais: | 11/29/2017 |
| Paredzētā reģistrācija iesniegta: | 11/29/2017 |
| Pirmais izlikts: | 12/05/2017 |
| Pēdējais atjauninājums iesniegts: | 07/24/2019 |
| Pēdējā atjaunināšana ievietota: | 07/28/2019 |
| Faktiskais studiju sākuma datums: | 01/16/2018 |
| Paredzamais primārās pabeigšanas datums: | 03/01/2018 |
| Paredzamais pētījuma pabeigšanas datums: | 03/01/2018 |
Stāvoklis vai slimība
Iejaukšanās / ārstēšana
Other: Chocolate
Fāze
Roku grupas
| Roka | Iejaukšanās / ārstēšana |
|---|---|
| Chocolate Participants will be asked to taste commercially available chocolate varying in sugar, fat and percent cocoa (milk, 70%, 85% and 90% cocoa). | Other: Chocolate Participants will be asked to taste commercially available chocolate varying in sugar, fat and percent cocoa (milk, 70%, 85% and 90% cocoa). |
Atbilstības kritēriji
| Vecums, kas piemērots studijām | 18 Years Uz 18 Years |
| Dzimumi, kas ir piemēroti studijām | All |
| Paraugu ņemšanas metode | Non-Probability Sample |
| Pieņem veselīgus brīvprātīgos | Jā |
| Kritēriji | Inclusion Criteria: - body mass index 20-30 kg/m2 - free of any major illness or disease Exclusion Criteria: - food allergies - participation in a weight loss diet or exercise program - pregnancy - lactation - metabolic illness or disease (diabetes, renal failure, thyroid illness, hypertension) - eye illness or disease (narrow angle glaucoma, macular degeneration, retinal detachment, cataracts) - psychiatric, neurological or eating disorders (schizophrenia, depression, Parkinson's Disease, Huntington's Disease, cerebral palsy, stroke, epilepsy, anorexia nervosa or bulimia nervosa) - take prescription medications except for oral contraceptives or antihyperlipidemia agents |
Rezultāts
Primārie rezultāti
1. Retinal dopamine response to oral stimuli [30 minutes]
2. Psychoactive Effects Questionnaire in response to oral stimuli [30 minutes]
Sekundārie iznākuma mērījumi
1. Scores on the Binge Eating Scale will correlate with the retinal dopamine and Psychoactive Effect Questionnaire responses [30 minutes]
