Effects of Cocoa Flavanol on Skin Aging

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Ielogoties Reģistrēties

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StatussPabeigts

Sponsori

Seoul National University Hospital

KLĪNISKĀ IZPĒTE: NCT02060097

BioSeek: NCT02060097

Atslēgvārdi

Abstrakts

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.

Datumi

Pēdējoreiz pārbaudīts:	05/31/2016
Pirmais iesniegtais:	02/08/2014
Paredzētā reģistrācija iesniegta:	02/08/2014
Pirmais izlikts:	02/10/2014
Pēdējais atjauninājums iesniegts:	06/10/2016
Pēdējā atjaunināšana ievietota:	06/13/2016
Faktiskais studiju sākuma datums:	01/31/2014
Paredzamais primārās pabeigšanas datums:	02/28/2015
Paredzamais pētījuma pabeigšanas datums:	02/28/2015

Stāvoklis vai slimība

Ageing

Photo-aging

Iejaukšanās / ārstēšana

Dietary Supplement: Cocoa flavanol beverage

Dietary Supplement: Placebo beverage

Fāze

Roku grupas

Roka	Iejaukšanās / ārstēšana
Active Comparator: Cocoa flavanol beverage flavanol 320mg/day	Dietary Supplement: Cocoa flavanol beverage
Placebo Comparator: Placebo beverage no flavanol	Dietary Supplement: Placebo beverage

Atbilstības kritēriji

Vecums, kas piemērots studijām	40 Years Uz 40 Years
Dzimumi, kas ir piemēroti studijām	Female
Pieņem veselīgus brīvprātīgos	Jā
Kritēriji	Inclusion Criteria: - Healthy females aged ≥ 40 years - Facial wrinkle grade ≥ 2 Exclusion Criteria: - received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study - reported taking functional foods 1 month before the study - history of acute or chronic disease such as severe liver or kidney disease or uncontrolled diabetes - history of allergies against any component of trial foods - any visible skin disease that might be confused with a skin reaction to the test procedure

Rezultāts

Primārie rezultāti

1. Change from baseline in skin wrinkles at week 24 [baseline, week 24]

Facial wrinkles in the crow's feet area measured as R1-3

Sekundārie iznākuma mērījumi

1. Change from baseline in skin elasticity at week 24 [baseline, week 24]

Facial elasticity measured as R2, R5, R7

2. Change from baseline in minimal erythema dose at week 24 [baseline, week 24]

3. Change from baseline in skin hydration at week 12 [baseline, week 12]

Skin hydration measured by Corneometer

4. Change from baseline in skin color at week 12 [baseline, week 12]

Skin color measured as erythema index and melanin index