Effects of Probiotics and Electrophysiologic Therapy on Endometrium Repair
Atslēgvārdi
Abstrakts
Apraksts
Post-traumatic repair disorder of endometrium can cause intrauterine adhesions, amenorrhea and infertility, which seriously endanger women's reproductive health. In our previous study, high throughput sequencing of intrauterine microorganisms showed that the content of lactic acid bacteria in the uterine cavity of patients with intrauterine adhesions was significantly lower than that of normal people. Concurrently, our previous studies found that chronic endometritis can aggravate endometrial fibrosis, then affect the repair of endometrial trauma, and increase the recurrence of intrauterine adhesion. Our previous study also suggest that stem cells are beneficial to the repair of endometrium. Studies have shown that lactic acid can inhibit inflammatory response and regulate the proliferation of intestinal stem cells. So can lactic acid also change the microbial environment in uterine cavity to inhibit endometrial inflammation and regulate the proliferation of endometrial stem cells to help repair endometrial wounds? In addition, electrical stimulation can relieve depression and anxiety and play a sedative effect. In recent years, some studies have shown that pelvic floor electrophysiological therapy can improve the intimal blood flow resistance index of thin endometrium. Therefore, whether or not the pelvic floor electrophysiological therapy can repair the endometrium after the intrauterine adhesion. We expect probiotics and electrophysiologic therapy can promote endometrial repair after electrosurgical resection of intrauterine adhesions.
Datumi
Pēdējoreiz pārbaudīts: | 04/30/2019 |
Pirmais iesniegtais: | 05/28/2019 |
Paredzētā reģistrācija iesniegta: | 05/28/2019 |
Pirmais izlikts: | 05/30/2019 |
Pēdējais atjauninājums iesniegts: | 05/28/2019 |
Pēdējā atjaunināšana ievietota: | 05/30/2019 |
Faktiskais studiju sākuma datums: | 05/04/2019 |
Paredzamais primārās pabeigšanas datums: | 11/30/2020 |
Paredzamais pētījuma pabeigšanas datums: | 11/30/2020 |
Stāvoklis vai slimība
Iejaukšanās / ārstēšana
Drug: probiotic group
Device: Electrophysiologic therapy group
Fāze
Roku grupas
Roka | Iejaukšanās / ārstēšana |
---|---|
Experimental: probiotic group apply probiotic after surgery | Drug: probiotic group apply probiotic after operation |
Experimental: Electrophysiologic therapy group apply electrophysiologic therapy after surgery without probiotic | Device: Electrophysiologic therapy group Pelvic floor electrophysiological therapy is used after surgery |
No Intervention: control without electrophysiologic therapy and probiotic after surgery |
Atbilstības kritēriji
Vecums, kas piemērots studijām | 20 Years Uz 20 Years |
Dzimumi, kas ir piemēroti studijām | Female |
Pieņem veselīgus brīvprātīgos | Jā |
Kritēriji | Inclusion Criteria: (1) Preoper- ative AFS score was ≥9; (2) the prior menstrual cycle was regular, and the sex hormone was normal; (3) patients had fertility requirement; (4) male semen examination appeared normal; (5) there were no severe systemic diseases and no contradictions to aspirin, estrogen, and surgery Exclusion Criteria: (1) Preoperative AFS score was <9; (2) prior menstrual cycle was irregular and sex hormone was abnormal, or patients had endocrine factors that caused amenorrhea, menstrual reduction, and infertility; (3) patients had no fertility requirement; (4) patients had male factor infertility; (5) patients had contradictions to estrogen and aspirin such as cancers (breast cancer and endometrial cancer), thrombotic diseases, allergy to antipyretic anal- gesics, severe liver injury, hypoprothrombinemia, vitamin K deficiency, hemophilia, thrombocytopenia, and gastric or duodenal ulcer and asthma |
Rezultāts
Primārie rezultāti
1. Endometrial Thickness [Within the first 3 months after surgery]
Sekundārie iznākuma mērījumi
1. Menstruation Pattern of All Participants [Within the first 3 months after surgery]
2. Reduction of American Fertility Society adhesion score at Second-look hysteroscopy of All Participants [Within the first 3 months after surgery]