Turmeric and Turmeric-containing Tablets and Sebum Production
Atslēgvārdi
Abstrakts
Apraksts
Turmeric (Curcuma longa) is a spice that has been shown to exhibit anti-inflammatory, antimicrobial, antioxidant, anti-neoplastic properties, and even potential to improve mental illnesses. In western herbalism, Turmeric is primarily used as an anti-inflammatory agent. In India, turmeric is used in Ayurvedic medicine for the treatment of acne. It has been used both internally and externally.
Curcumin is a phytochemical derived from turmeric and believed to be one of the key active components of turmeric. Curcumin is reported to have activity as an antibacterial and anti-inflammatory agent and has been used as a paste for skin eruptions and infections. Previous basic science work by Dr. Raja Sivamani's lab has shown that both turmeric and curcumin inhibit lipid synthesis in human sebocytes, the cells responsible for the production of sebum
The goal of this study is to evaluate how ingestion of turmeric and tablets that have a combination of herbs including turmeric may modulate sebum production.
Datumi
| Pēdējoreiz pārbaudīts: | 11/30/2018 |
| Pirmais iesniegtais: | 10/31/2016 |
| Paredzētā reģistrācija iesniegta: | 02/21/2017 |
| Pirmais izlikts: | 02/27/2017 |
| Pēdējais atjauninājums iesniegts: | 12/17/2018 |
| Pēdējā atjaunināšana ievietota: | 12/19/2018 |
| Faktiskais studiju sākuma datums: | 10/31/2016 |
| Paredzamais primārās pabeigšanas datums: | 08/27/2017 |
| Paredzamais pētījuma pabeigšanas datums: | 08/27/2017 |
Stāvoklis vai slimība
Iejaukšanās / ārstēšana
Dietary Supplement: Turmeric group
Dietary Supplement: Turmeric-containing combination tablets
Dietary Supplement: Placebo tablets group
Fāze
Roku grupas
| Roka | Iejaukšanās / ārstēšana |
|---|---|
| Active Comparator: Turmeric group 2,000 mg turmeric per day - supplied by Banyan® Botanicals )
o Each tablet contains 500 mg of Turmeric (Curcuma longa). Subjects will take 2 tablets twice per day, with a total daily dose of 2,000 mg. | Dietary Supplement: Turmeric group |
| Active Comparator: Turmeric-containing combination tablets • 2,000 mg Healthy Skin™ Tablets, contains:
Turmeric (Curcuma longa) - 50 mg/tablet
Hemidesmus Indicus root (Anantamul)
Indian Madder root
Neem leaf
Gotu Kola leaf
Indian TInospora stem
Amla fruit
Licorice root
Phyllanthus Amarus herb Each tablet contains 500mg total of the above herbs. There is 50 mg of Turmeric in each Healthy Skin ™ tablet. Subjects will take 2 tablets twice per day, which will be a total daily dose of 200 mg of Turmeric. This is comparable to the daily amount of Turmeric in many commercially-available Turmeric supplements; therefore, it is valuable to compare this formulation to the turmeric-only tablets. | Dietary Supplement: Turmeric-containing combination tablets |
| Placebo Comparator: Placebo tablets group Supplement appearing similar to those in the turmeric and curcumin groups, supplied by Banyan® Botanicals
Ingredients (all organic): Placebo ingredients: Rice hulls concentrate, Maltodextrin, Micro Crystalline Cellulose, Beet Root Powder, Dutch coco powder
Dose: subjects in this group will take 2 tablets twice per day | Dietary Supplement: Placebo tablets group |
Atbilstības kritēriji
| Vecums, kas piemērots studijām | 18 Years Uz 18 Years |
| Dzimumi, kas ir piemēroti studijām | All |
| Pieņem veselīgus brīvprātīgos | Jā |
| Kritēriji | Inclusion Criteria: 1. Age 18 to 50 years of age, and 2. Subject must be able to read and comprehend study procedures and consent forms. Exclusion Criteria: 1. Subject should be generally healthy and have no smoking history in the past one year, and must have no history of diabetes, metabolic syndrome, known cardiovascular disease, malignancy, kidney disease, or chronic steroid use. 2. Subjects who consume more than 6 servings of caffeine per day, such as coffee and energy drinks (example - Red Bull). 3. Subjects with known allergies to herbal ingredients. 4. Subjects with known EKG changes. 5. Those who used topical medications in the past two weeks or systemic antibiotics within one month of starting the study. 6. Subjects who are postmenopausal 7. Those who are pregnant or breastfeeding. 8. Those that are prisoners or cognitively impaired. |
Rezultāts
Primārie rezultāti
1. Change in facial Sebum production at 4 weeks [4 weeks]
Sekundārie iznākuma mērījumi
1. Change from baseline in sebum profile, such as inflammatory markers, at 4 weeks [4 weeks]
