A New Rosmarinic Acid Derivative from Isodon oresbius.

Phytochemical reinvestigation of ISODON ORESBIUS afforded, in addition to oleanolic acid, ursolic acid, sodoponin, astragalin, and quercetin-3- O-glucoside, three known (oresbiusin A, rosmarinic acid and methyl rosmarinate) and a new rosmarinic acid derivative as well as an ENT-kaurene diterpenoid, neo-angustifolin, characterized as a separated component for the first time. By a combination of 1D- and 2D-NMR techniques the structure of the new compound was established as butyl rosmarinate. The IN VITRO antifungal assay showed that neoangustifolin was active against CANDIDA ALBICANS with the MIC being 50 microg/ml.