Twelve patients found to be colonized with C. difficile will undergo twice a day potato starch supplementation.

Clostridium Difficile

Hematologic Diseases

Potato starch will be given twice a day for up to 14 days, discharge, or death, whichever occurs first.

Potato starch

Medical College of Wisconsin

Oligosaccharide for Cdiff(+) Heme-onc Patients

Oligosaccharide Supplementation Among Hematology-Oncology Clostridium Difficile Colonized Patients

Samples will be collected twice a week (4-5 times during supplementation) and one time at day 21 or discharge, whichever happens first.

Patients will be provided with a diary in which they will document compliance with oligosaccharide intake. It is anticipated ≥70% of intended doses to be fully administered by the patient.

It is expected ≥50% of stool samples to be correctly collected and processed.

Stool samples collected for diagnosis and any additional stool collections will be thawed in batches and one cc aliquot will be extracted refreezing the remaining sample at -80 degrees F. One cc aliquot will then be divided into 4 sub-samples of equal volume and with the same unique identifier. This identifier will be able to chronologically cluster samples by each unique patient. A sample will be used for C. difficile qPCR quantitative determination.

Sub-sample of stool from diagnosis, and additional stool collections will be used for 16S ribosomal ribonucleic acid gene sequencing to determine the microbiome community structure

Siliva Munoz-Price

Professor

Each participant will have to eat scrambled egg on day 1 and porridge on day 2; both meals will contain the radioactive tracer 99mTc-DTPA.
Participants will be scanned by a trained technologist. The scans will be carried out using a General Electric, Discovery 360 Gamma Camera.The scanning process will take approximately three hours in total, however the imaging will be carried out in stages.

abdominal pain/kartupelis

Oligosaccharide for Cdiff(+) Heme-onc Patients

Gastric Emptying: in Vivo Studies in Healthy Volunteers

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