azotemia/glutathione

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Lack of effect of glutathione depletion by L-buthionine-S,R-sulfoximine on gentamicin nephrotoxicity in rats.

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The mechanism of gentamicin-induced renal proximal tubular cell injury is not known, but generation of reactive oxygen species with subsequent lipid peroxidation has been proposed. In this study, male adult rats were given gentamicin and L-buthionine-S,R-sulfoximine (BSO), a selective glutathione

Comparative evaluation of taurine and thiotaurine as protectants against diabetes-induced nephropathy in a rat model.

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Taking into account the proven effectiveness of antioxidants in preventing experimentally induced diabetes in laboratory animals, this study was carried out with the specific purpose of comparing the effectiveness of two known antioxidants, the β-aminosulfonate taurine (TAU) and β-aminothiosulfonate

Diet modulates the toxicity of cancer chemotherapy in rats.

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The effects of diet and folate status on cyclophosphamide or 5-fluorouracil toxicity were studied in Fischer 344 rats maintained on either a cereal-based diet or a purified diet (AIN-93G). The rats fed the purified diet were divided into 3 groups: folate deficient (no dietary folic acid), folate

Hypoperfusion-induced acute renal failure in the rat: an evaluation of oxidant tissue injury.

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Ielogoties Reģistrēties

Reactive oxygen species (ROS) have been reported to be critical cellular mediators of experimental ischemic acute renal failure (ARF). This conclusion is based on observations that in the renal artery occlusion (RAO) model of ARF, antioxidant drugs confer protection and that renal malondialdehyde

Relationships between oxidative stress markers and red blood cell characteristics in renal azotemic dogs.

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Ielogoties Reģistrēties

Oxidative stress parameters and erythrocyte characteristics were studied in 15 normal healthy dogs and 33 renal azotaemic dogs from Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. Dogs with renal azotaemia had reduced mean corpuscular volume (MCV) (P<0.01), packed

[Oxidative stress in kidney failure: an experimental study].

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Ielogoties Reģistrēties

We studied the activity of some enzymes directly involved in the endogenous antioxidative defense system: glutathione-peroxidase (GPX), glutathione s-transferase (GST) and superoxide dismutase (SOD). We have investigated the effects of selenium and vitamin E diet supplementation, in form of

Acute renal failure due to acetaminophen ingestion: a case report and review of the literature.

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Ielogoties Reģistrēties

Acetaminophen is the most commonly reported drug overdose in the United States. Acute renal failure occurs in less than 2% of all acetaminophen poisonings and 10% of severely poisoned patients. At the therapeutic dosages, acetaminophen can be toxic to the kidneys in patients who are glutathione

Urinary and serum biomarkers for the diagnosis of acute kidney injury: an in-depth review of the literature.

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Ielogoties Reģistrēties

BACKGROUND Acute kidney injury (AKI) remains associated with high morbidity and mortality, despite progress in medical care. Although the RIFLE (Risk, Injury, Failure, Loss, End-Stage Kidney Disease) and AKIN (Acute Kidney Injury Network) criteria, based on serum creatinine and urine output, were a

A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients

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Ielogoties Reģistrēties

The identification of natural bioactive compounds, able to counteract the abnormal increase of oxidative stress and inflammatory status in chronic degenerative non-communicable diseases is useful for the clinical management of these conditions. We tested an oral food supplement (OFS), chemically

Salutary effects of a novel oxidative stress modulator on adenine-induced chronic progressive tubulointerstitial nephropathy.

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Ielogoties Reģistrēties

BACKGROUND Oxidative stress and inflammation promote the development and progression of chronic kidney disease. Oxidative stress is associated with depletion of tissue glutathione (GSH), the most abundant endogenous intracellular antioxidant, but degradation of oral GSH by digestive enzymes limits

Partial aortic ligation: a hypoperfusion model of ischemic acute renal failure and a comparison with renal artery occlusion.

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Ielogoties Reģistrēties

Ischemic acute renal failure (ARF) in humans typically results from hypoperfusion, not total blood flow interruption. However, experimental studies of ischemic ARF have relied on total blood flow cessation models because no reliable hypoperfusion model has been described. Therefore, the goal of this

Studies of mechanisms and protective maneuvers in myoglobinuric acute renal injury.

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Ielogoties Reģistrēties

To explore why urine pH affects myoglobin (M)-induced renal injury, rats were infused with M under aciduric (NH4Cl) or alkalinuric (KHCO3) conditions with or without additional solute loading. Acute renal M retention (R) was highly pH dependent (pH 5.77, 68% R; pH 6.45, 49% R; pH 8.0, 28% R), the %

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