Depending on body weight, patients will be divided into two groups. Women with a body weight <70 kg will be taking a daily dose of 800 mg ibuprofen orally. Women ≥ 70 kg will take a dose of 1200 mg ibuprofen orally. Before and after 3 weeks of treatment, all subjects will have a full hormonal, biochemical and clinical profile.

PCOS

Hyperandrogenism

Inflammation

800 mg/day ( 2 x 400mg) for 3 weeks in women with a bodyweight <70 kg, and a dose of 1200 mg/day (3x400mg) in women weighing> 70kg. The effects of treatment will be compared on the basis of changes in the hormonal profile and inflammatory markers, as well as the clinical assessment of the patient.

Ibuprofen

Division of Infertility and Reproductive Endocrinology, Department of Gynecology and Obsterics

The Effect of Ibuprofen on Women With PCOS.

The Effect of Ibuprofen on the Endocrine and Metabolic Status of Women With PCOS.

hirsutism evaluation ( Ferriman-Gallway score, acne evaluation, androstendion, DHEA-S, SHBG level evaluation)

Beata Banaszewska

MD PhD Associate Proffesor Division of Infertility and Reproductive Endocrinology, Department of Gynecology and Obsterics

Poznan University of Medical Sciences

Patients 18 to 80 years old diagnosed of severe asthma, requiring treatment at least with LABA+ high doses ICS, with eosinophil count in blood<300/mm3. They must be ex-smokers with less than 10 packs-year and no other relevant pulmonary disease.

Neutrophilic Asthma

Characterization with flow cytometry of the phenotype of the neutrophils isolated in the sputum, microbiome

Induced sputum

Website of the spanish guideline of asthma

Website of the european guideline of asthma

Hospital de la Santa Creu i Sant Pau. Carrer Mas Casanovas 90.

Non-Eosinophilic Neutrophilic Asthma

Asma Neutrofílica y No Eosinofílica

To determine the types of neutrophils (in induced sputum and blood) associated with neutrophilic asthma and its subphenotypes according to flow citometry

To analyse the bronchial microbiological flora of neutrophilic asthma

To describe the clinical characteristics and natural history of the neutrophilic asthma and its subphenotypes

chlamydia infections/aptaukošanās

The Effect of Ibuprofen on Women With PCOS.

Non-Eosinophilic Neutrophilic Asthma

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