Lappuse 1 no 477 rezultātiem
Objective: This study was performed to investigate the effect of microRNA-135b-5p (miR-135b-5p) on endothelial cell proliferation and angiogenesis in diabetic retinopathy (DR) mice with the involvement of Von Hipp-el-Lindau protein (VHL) and hypoxia-inducible factor 1 α
Risk factors of tissue hypoxia was investigated in 26 patients with diabetic retinopathy (DMR), who compared with 62 patients without DMR. significant higher incidence of DMR was found in patients with poor diabetic control (HbA 1 greater than or equal to 10%), with orthostatic hypotension (OH),
Diabetes causes various biochemical changes in the retina; long-term changes in the factors associated with hypoxia and gliosis have rarely been reported. The present study was conducted to explore the changes in these factors in a time-dependent manner in experimental diabetic retinopathy (DR).
Diabetic retinopathy (DR) is a serious condition that can cause blindness in diabetic patients. It is a neurovascular disease, but the pathogenesis leading to the onset of this disease is still not completely understood. However, hypoxia with subsequent neovascularization is a characteristic
Diabetic retinopathy is associated with hyperglycemia, and there is convincing evidence that oxidative stress (the overproduction of reactive oxygen species (ROS)) measured indirectly in patients, is related to the severity of diabetic complications. Also, reducing such stress by various means,
OBJECTIVE
To clarify the relationship between evaluation items of sleep-disordered breathing and diabetic retinopathy in detail.
METHODS
Cross-sectional comparative study.
METHODS
Sixty-eight consecutive nonproliferative diabetic retinopathy and 151 proliferative diabetic retinopathy (PDR) cases who
The primary aim of these experiments was to assess in vitro effects of hyperglycemia (30 mmol/l glucose) and hypoxia (Po(2) = 36 torr) of 2-h duration, separately and in combination, on cytosolic and mitochondrial free NADH (NADHc and NADHm, respectively) in retinas from normal rats. NADH is the
OBJECTIVE
To determine vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1a (HIF-1a) in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR).
METHODS
Observational case-control study.
METHODS
Serum and vitreous fluid samples were obtained during
OBJECTIVE
Retinal Müller cells are known to produce inflammatory and angiogenic cytokines, which play important roles in diabetic retinopathy. Hypoxia-inducible factor (HIF)-1 has been shown to play a crucial role in retinal inflammation and neovascularisation. We sought to determine the role of
Retinal vasculature changes in diabetic patients are most common cause of blindness among eye diseases. Numerous studies have explored the role of the agiogenic factors in the progression of diabetic retinopathy (DR). The balance between angiogenic and antiangiogenic factors has a determining role
The microvascular complications in the retina and kidneys are preceded and accompanied by functional abnormalities. The appearance of the first retinal responses, venous dilatation associated with increased plasma permeation, suggest a state of tissue hypoxia located close to the venous
BACKGROUND
Obstructive sleep apnea (OSA) is common in obese patients with type 2 diabetes mellitus (DM) and may contribute to diabetic microvascular complications.
METHODS
To investigate the association between OSA, hypoxemia during sleep, and diabetic retinal complications in severe obesity. This
Diabetic retinopathy is the most common chronic microvascular complication associated with diabetes mellitus. The development of diabetic retinopathy is a consequence of metabolic dysregulation. Hyperglycemia is a critical factor which is involved in basement membrane thickening, loss of pericytes
Diabetic retinopathy (DR) is a retinal disease which is one of the most severe complications occuring due to diabetes mellitus and is a major cause of blindness. Patients who have diabetes mellitus for number of years develop characteristic group of lesions in the retina which leads to Diabetic