epinephrine/necrosis

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Role of calcium and free fatty acids in epinephrine-induced myocardial necrosis.

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Ielogoties Reģistrēties

A possible mechanism by which large doses of catecholamines produce myocardial necrosis was investigated. Male Sprague-Dawley rats, 275 to 325 g in weight, were injected once, sc, with 3 mg/kg epinephrine (E) or infused iv for 1 hr with E at a rate of 1.2 or 1.7 micrograms/min, and also injected iv

Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700).

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Ielogoties Reģistrēties

AVE8062, a derivative of combretastatin A-4, has a strong stanching effect on tumour blood flow (TBF), which leads to complete blockage of nutrient supply to solid tumours and their necrosis. Previously, we reported that TBF stasis is due to increased arteriolar resistance caused by AVE8062 and a

The role of epinephrine in the reactions produced by the endotoxins of gram-negative bacteria. I. Hemorrhagic necrosis produced by epinephrine in the skin of endotoxin-treated rabbits.

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Ielogoties Reģistrēties

Extensive lesions of dermal hemorrhagic necrosis occurred in rabbits when epinephrine (or norepinephrine) was injected into the skin within 4 hours after an intravenous injection of endotoxin. As little as 5 microg. of intradermal epinephrine, and 1 microg. of intravenous endotoxin, were sufficient

Mechanism of epinephrine enhancement of lidocaine-induced skeletal muscle necrosis.

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Ielogoties Reģistrēties

Epinephrine significantly increases lidocaine-induced skeletal muscle necrosis, even in low concentrations that elicit no damage by themselves. Inasmuch as isoproterenol had no influence on lidocaine myotoxicity, a direct effect of epinephrine on muscle fibers is unlikely. Two vasoconstrictors with

[Effects of oxyfedrine on high blood viscosity and myocardial necrosis induced by epinephrine and ice water stress in rats].

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Ielogoties Reģistrēties

Acute high blood viscosity (HBV) and myocardial necrosis was established by epinephrine (Epi) and ice water stress in rats. Effects of iv oxyfedrine (Oxy) on HBV, plasma viscosity (PV), hematocrit, erythrocyte electrophoretic time (EET), and fibrinogenic viscosity (FV) were studied in model. Results

[Digital necrosis after local anaesthesia with epinephrine].

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Ielogoties Reģistrēties

BACKGROUND To date, there is a lack of consensus concerning the application of local anaesthetics with epinephrine in fingers, due to the alleged risk of ischaemic complications. METHODS We present the case of a 70-year old woman, with a medical history of diabetes mellitus and an ischemic cerebral

Epinephrine induced myocardial necrosis: effects of aminophylline and adrenergic blockade.

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Ielogoties Reģistrēties

The pathogenesis of myocardial necrosis produced in the albino rat by a single large dose of the potent alpha and beta adrenergic agonist epinephrine was investigated. In confirmation and extension of earlier observations with the alpha adrenergic antagonist tolazoline, it was found that alpha

[Eyelid necrosis after injection of lidocaine with epinephrine].

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Ielogoties Reģistrēties

Four patients (two women aged 50 and 67 years, a 36-year-old man, and a 5-year-old child) presented with necrosis of the eyelid after local anesthesia using 2% lidocaine with epinephrine. In three cases, the anesthesia was administered prior to suturing an eyelid laceration, and the necrosis

Protective effect of ethanol against epinephrine-induced myocardial necrosis in rats.

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Ielogoties Reģistrēties

Myocardial necrosis was produced in rats by the subcutaneous injection of a single dose of epinephrine (3 mg base/kg). The severity of the cardiac injury produced was assessed by visual inspection, determination of the release of LDH, CPK, GOT, and HBDH from isolated perfused hearts, and measurement

Epinephrine attenuates down-regulation of monocyte tumor necrosis factor receptors during human endotoxemia.

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Ielogoties Reģistrēties

Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis

Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10.

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Ielogoties Reģistrēties

Epinephrine has been found to inhibit the production of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha and to enhance the production of anti-inflammatory cytokine interleukin (IL)-10. To determine the effect of epinephrine on IL-1 beta production, the following experiments were

Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: relation to pathogenesis of catecholamine cardiomyopathy.

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Ielogoties Reģistrēties

We have examined the effects of adrenochrome and other metabolites of epinephrine on the ultrastructure and contractile activity of isolated rat hearts perfused under conditions in which the heart rate and coronary flow were controlled. Perfusion of hearts with epinephrine or metanephrine

Digital Necrosis After Lidocaine and Epinephrine Injection in the Flexor Tendon Sheath Without Phentolamine Rescue.

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Ielogoties Reģistrēties

The literature generally supports the safety of epinephrine injection in the digits, but recent case reports describe ischemic adverse events associated with the use of lidocaine and epinephrine in which phentolamine rescue was not performed. We present a case of finger necrosis and subsequent

Finger injection with high-dose (1:1,000) epinephrine: Does it cause finger necrosis and should it be treated?

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Ielogoties Reģistrēties

OBJECTIVE Accidental finger injections with high-dose (1:1,000) epinephrine is a new and increasing phenomenon. The purpose of this study is to document the incidence of finger necrosis and the treatment for this type of injury. The necessity or type of treatment required for this type of injury has

Epinephrine Injection Associated Scrotal Skin Necrosis.

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Ielogoties Reģistrēties

Male circumcision is among the most frequent surgical interventions throughout history. Although considered as a minor intervention, it may have complications ranging from insignificant to catastrophic. These complications can be attributed to the surgical procedure and anesthesia. In this report we

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