Laboratory Blood Test For the development of the new biomarkers using the technique of Mass-spectrometry 7,5 ml EDTA blood and a dry blood spot filter card are taken. To proof the correct Gilbert diagnosis in those patients where up to the enrollment in the study no genetic testing has been done, sequencing of Gilbert disease will be done. The analyses will be done at: Centogene AG Am Strande 7 18055 Rostock Germany

Meulengracht Syndrome

Hyperbilirubinemia

Unconjugated Benign Bilirubinemia

Centogene is one of the leading laboratories focusing on genetic testing for rare hereditary disorders. We now offer more than 2200 routine genetic and biochemical tests.

Children Hospital, Faculty of Medicine, Cairo University

Amrita Institute of Medical Sciences & Research Centre

Navi Mumbai Institute of Research In Mental And Neurological Handicap (NIRMAN)

Lady Ridgeway Hospital for Children

Biomarker for Gilbert Disease (BioGilbert)

Biomarker for Gilbert Disease - An International, Multi- Center, Epidemiological Protocol

Next-Generation Sequencing (NGS) of the UGT1A1 gene will be performed. The mutation will be confirmed by Sanger sequencing.

The quantitative determination of small molecules (molecular weight 150-700 kD, given as ng/μl) within a dried blood spot sample will be validated via liquid chromatography multiple reaction-monitoring mass spectrometry (LC/MRM-MS) and compared with a merged control cohort. The statistically best validated molecule will be considered as a disease specific biomarker.

Centogene AG Rostock

This group will meet the same inclusion and exclusion criteria as the group receiving the study drug

This arm will receive the active medication dutasteride

Hypogonadism

0.5mg by mouth one time per day for 1 year

dutasteride

placebo

Men's Health Boston

The Miriam Hospital

Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement

Dutasteride in Men Receiving Testosterone Therapy: Impact on Serum PSA, Testosterone, DHT Levels and Prostate Volume: "Implications for Prostate Safety"

gilbert disease/fatigue

Biomarker for Gilbert Disease (BioGilbert)

Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement

Vispilnīgākā ārstniecības augu datu bāze, kuru atbalsta zinātne