Subjects assigned to control group receives only a booklet including the recommendations for a correct diet by the Italian National Institute for Research on Food and Nutrition (INRAN), presently called (CRA-NUT) .

Subjects assigned to the intervention group will follow a nutritional pathway based on a Mediterranean diet pattern for 4 months and receive suggestions on the regular practice of physical activity, under the guide of some nutritionists, who will propose individualized diets for each subject.
All subjects of both groups will undergo urologic examination, measurement of weight, height and abdominal circumference, an interview on demographic data and lifestyle variables, and will provide blood and semen samples in fasting conditions, at the enrollment (baseline), at the end of the intervention phase (after 4 months) and at the end of follow-up (after 8 months).

Fertility Disorders

Gender-based eligibility is directly related to the main purpose of the study, that is to evaluate the effects of lifestyle changes on male germ cells

Nutritional plan and Physical activity goals

lifestyle counseling

Urology Unit "S. Francesco d'Assisi" Hospital

Unit of Hygiene, Epidemiology and Public Health, University of Brescia

Unit of Urology - Istituto Clinico Città di Brescia

Dpt. of Food safety, nutrition and veterinary public health, Italian National Institute of Health (ISS)

Effects of Lifestyle Changes on Semen Quality in Healthy Young Men Living in Highly Polluted Areas (FAST)

An Intervention Model for the Prevention of Infertility in Healthy Young Men Living in Highly Polluted Areas

Total Antioxidant Capacity, measured in semen samples (mM)

Prostate-Specific Antigen in seminal plasma and in blood serum, measured in ng/ml

DNA-methylation status of Alu and L1 sequences

dosage of trace elements in seminal plasma, semen and blood serum

LUIGI MONTANO

Principal Investigator

Azienda Sanitaria Locale Salerno

Istituto clinico Città di Brescia

Università degli Studi di Brescia

Istituto Superiore di Sanità

Ministero della Salute, Italy

ISA-CNR, Avellino

Molecular Epidemiology and Environmental Epigenetics Lab

Primary purpose of the study is the improvement of semen quality in healthy young men living in highly polluted areas, operating on two specific lifestyle factors, that are nutrition and physical activity. Overall, 450 subjects will be enrolled (150 for single recruiting area) and they will be assigned by chance to one of the two arms of the study, named "Control group" and "Intervention group". Every subject is identified by means of an individual alphanumeric code that does not specifies which group they belong to, in order to mask to all the outcomes assessors the membership to one arm or another.

A specific alphanumeric code is assigned to each participant

Subgroup A1: Consist of ceramic on metal THAs with short term follow-up (less than 2years)
Subgroup A2: Consist of ceramic on metal THAs with midterm follow-up (more than 2years)
Subgroup A3: Consist of bilateral ceramic on metal THAs

Patients without any implant or systemic disease, to served as controls

Hip Replacement Arthroplasty

Patients have THA with ceramic on metal articulation

Ceramic on Metal Articulation

Patients have THA with non-ceramic on metal articulation

Non-Ceramic on Metal Articulation

Korea University Guro Hospital

Serum Level of Cobalt and Chromium After Ceramic on Metal Articulation Total Hip Arthroplasty

Blood sampling will be performed 2 times during follow-up outpatient clinic visits.
Second sampling is performed 3 months after first sampling.

A CADD based software POLYWARE (Draftware Inc, CAD viewing and medical image analysis products, Warsaw, Indiana).It is a three-dimensional technique for the measurement of polyethylene wear in metal backed acetabular components. Using a back-lit digitizing tablet, points from AP and Lateral radiographs are captured by AutoCAD software. Custom programming converts the point data into 3D solid models of the prosthesis. The Migration of the Head/cup center points are used to calculate volume displacement.

Digitalized radiographs of pelvis; standard anteroposterior and lateral oblique radiographs to measure acetabular osteolysis, ante version and abduction angles, a shoot through radiograph to identify impingement and anterior edge loading.
Standard digitalized radiographs taken at 120% (PiView STAR, version5, Infinitt, Seoul, Korea) will be used for analysis of osteolytic lines in peg zones of femoral component as described by Amstutz and Delee and Charnley zones of the acetabular component.

Clinical evaluation through a questionnaire and physical examination

Infection
Hypersensitivity
Instability
Impingement
Fracture
loosening
Cardiomyopathy
Neurological changes including sensory change( auditory or visual impairment)
Psychological status change( including depression or cognitive impairment,)
Renal function impairment,
Thyroid dysfunction
Noises from the joint(popping, clicking, grinding or squeaking)

Won Yong Shon

Professor Won Yong Shon, Department of Orthopedic Surgery, Korea University Guro Hospital, Seoul.

HIV Infections

Cancer, Second Primary

175g probiotic yogurt / day 25% RDA for each nutrient

Probiotic Yogurt B: with various micronutrients

175g probiotic yogurt/ day 25% RDA for each nutrient

Probiotic Yogurt A: Kaiser micronutrients

175g yogurt/ day 25% RDA for each nutrient

molybdenum/vēzis

Effects of Lifestyle Changes on Semen Quality in Healthy Young Men Living in Highly Polluted Areas (FAST)

Serum Level of Cobalt and Chromium After Ceramic on Metal Articulation Total Hip Arthroplasty

Micronutrient Supplemented Probiotic Yogurt for HIV/AIDS and Other Immunodeficiencies

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