physostigmine/hypersensitivity

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The effect of cholinergic agents on a canine model of allergic asthma.

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Ielogoties Reģistrēties

Pharmacologic agents capable of influencing the activity of the cholinergic nervous system were evaluated for possible effects on a canine model of allergic asthma. Dogs with an active cutaneous sensitivity to an antigen (Ag) prepared from Ascaris suum were subjected to repeated aerosol Ag

Neuronal hypersensitivity to acetylcholinesterase inhibitors induced by a kindling stimulus in the rabbit brain.

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Ielogoties Reģistrēties

Kindling has been studied primarily with electrical stimuli applied to subcortical structures in the limbic system. Several recent pharmacological studies have implicated muscarinic cholinergic synapses in the genesis of limbic epilepsy. The present investigation was designed to test the hypothesis

Methacholine and physostigmine airway reactivity in asthmatic and nonasthmatic subjects.

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Ielogoties Reģistrēties

Inhalation challenges using methacholine and physostigmine were performed in 3 human asthmatic and 3 nonallergic normal subjects. Plethysmographic measurements of specific airways conductance (Gaw/Vtg) were used to monitor the response. The dose required to produce a 17% fall in Gaw/Vtg was

Cholinergic and adrenergic drugs affect delayed type hypersensitivity in C57BL/6 mice.

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Ielogoties Reģistrēties

The present study examined the influence of systemic administration of neuroactive drugs on delayed-type hypersensitivity (DTH) in C57BL/6 mice. The cholinergic agonist nicotine and the acetylcholinesterase inhibitor physostigmine decreased DTH, whereas the alpha-adrenergic agonist clonidine

Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus.

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Psychological stress may lead to long-lasting brain dysfunction, specifically altered emotional and cognitive capabilities. Previous studies have demonstrated persistent changes in the expression of key cholinergic genes in the neocortex and hippocampus following stress with muscarinic

The role of cholinergic supersensitivity in the medical symptoms associated with withdrawal of antipsychotic drugs.

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Ielogoties Reģistrēties

From a review of the clinical literature, the authors determined that the medical symptoms of neuroleptic withdrawal occurred more frequently with neuroleptics having potent anticholinergic effects than with those having weak anticholinergic actions. When antiparkinsonian agents were not

Hypothalamic-pituitary-adrenal regulation, neurotransmitters and affective disorders.

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Ielogoties Reģistrēties

Considerable evidence has accumulated indicating that alterations in neurotransmitters may play a role in the etiology of affective disorders on the one hand, and in the regulation of the limbic-hypothalamic-pituitary-adrenal axis (LHPA) on the other. Acetylcholine, norepinephrine, serotonin, GABA,

Anticholinergic properties of antipsychotic drugs and their relation to extrapyramidal side-effects.

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The effects of haloperidol, alone and in combination with atropine, were compared with the effects of clozapine, alone and in combination with physostigmine, in a variety of tests commonly used to characterize neuroleptic compounds. It was found that clozapine in combination with physostigmine did

Pharmacology of Huntington's chorea. Personal experience.

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Ielogoties Reģistrēties

Dipropylacetic acid (DPA), gamma-aminobutyric acid (GABA), physostigmine, CB 154 and butyrophenones were administered to 26 patients affected by Huntington's chorea. The evaluation of the pharmacologic activity of the different drugs was determined by means of some clinical parameters and motor

REM latency in neurotic and endogenous depression and the cholinergic REM induction test.

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Ielogoties Reģistrēties

Latency of rapid eye movement (REM) sleep was measured in eight healthy volunteers under baseline conditions and after administration of physostigmine. An infusion of 0.5 mg of physostigmine 5 minutes after sleep onset caused a significant shortening of REM latency in comparison with baseline

Cholinergic activity of intestinal muscle in vitro taken from horses with and without equine grass sickness.

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Ielogoties Reģistrēties

Equine grass sickness (EGS) is a pan-dysautonomia of horses that involves central and peripheral neuronal degeneration and ultimately depletion. This is the first reported functional study on the motility of equine intestine taken immediately post mortem from horses with EGS. Strips of smooth muscle

Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation.

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Ielogoties Reģistrēties

This study examined the effects of acute and chronic desipramine, 24-h total sleep deprivation (TSD) and 96-h REM sleep deprivation (REMSD) on physostigmine-induced hypothermia, analgesia and behaviour. The effects of acute and chronic desipramine treatment on oxotremorine-induced hypothermia were

Lung function requirements in flying duty the problem of bronchial hyperresponsiveness in military aircrew.

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Ielogoties Reģistrēties

Uncompromised lung function is essential for fitness to fly. Under hypobaric conditions there is an increased risk of hypoxemia. G-forces, positive pressure breathing and anti-G maneuvers cause physical stress to the lung tissue and altered pulmonary blood flow. Breathing with pure oxygen, dry cabin

Physiological mechanisms mediating enhanced force generation during development and immune sensitization.

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We examined the development of acetylcholinesterase (AChase) activity and tracheal smooth muscle (TSM) contraction elicited by acetylcholine (ACh) in a swine model of maturation and a dog model of allergic bronchospasm. Strips of TSM were tethered isometrically at optimal length and responses were

Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose.

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Ielogoties Reģistrēties

OBJECTIVE Diphenhydramine is an H1 histamine antagonist that is commonly used for allergic reactions, colds and cough, and as a sleep aid. In addition to anticholinergic and antihistaminergic effects, sodium channel blockade becomes evident following diphenhydramine overdose. While seizures may

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