Control Group:Benzydamine Hydrochloride spray by mouth three times daily for 20 days.
Follow up: The patients will be recalled at one week interval for 20 days.

Intervention group: 90% solcoseryl and 10% pumpkin seed oil spray by mouth three times daily for 20 days

Mucositis Oral

Patients will rinse by mouth three times daily for 20 days

Benzydamine Hydrochloride

Patients will receive by mouth three times daily for 20 days

Solcoseryl and pumpkin seed oil

Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Clinical Evaluation of Solcosreyl and Pumpkin Seed Oil Versus Benzydamine Hydrochloride in Management of Patients With Chemotherapy and Radiotherapy Induced Oral Mucositis

World Health Organization (WHO)scale.It is graded from 0 to 4. If the patient has no signs and symptoms, it is graded as 0. If the patient has painless ulcers, edema, or mild soreness, it is graded as 1. If there is painful erythema, edema, or ulcers but able to eat, it is graded as 2. If there is painful erythema, edema, or ulcers but unable eat, it is graded as 3. If there a requirement for parenteral or enteral support, it is graded as 4

Patient-Reported Oral Mucositis( PROMS scale) will measure Quality of life .The PROMS scale consists of 10, 100-mm horizontal visual analogue scales addressing oral functions affected by oral mucositis. Participants will be asked to mark a point on the line that best represents their present intra-oral condition.During the baseline examination and prior to their completion of the actual PROMS scale questionnaire, participants were subjected to a few training test-visual analogue scale questions focused on simple everyday topics to familiarize them with the concept of visual analogue scale assisted measurements. The participants will complete the PROMS questionnaire thrice; baseline, after the first week, and at the end of the study after the second week.

Ghada zaki

assistant lecturer at el ahram canadian university

Treatment will be placed in identical spray containers

Wharton Jelly Mesenchymal stem cells will be given as a cell suspension in aseptic buffered solution in disposable vials with no preservative agents. The cells will be injected every two weeks at a total of three doses, 120 million cells in 10mls divided on two IV boli for each dose

Inflammatory Bowel Diseases

Wharton Jelly Mesenchymal stem cells will be injected intravenously

Wharton Jelly Mesenchymal stem cells

Cell Therapy Center

Use of Mesenchymal Stem Cells in Inflammatory Bowel Disease

Ulcerative Colitis Stem Cell Therapy

Treatment adverse events are defined by any adverse event leading to hospitalization, organ failure or death

Remission will be considered if reaches 0 points and response if the score diminishes. Endoscopy will be performed at 0 and 12 weeks.

Hanan Jafar

DDS. MSc. PhD

Scientific Research Support fund

Aneurysmal Subarachnoid Hemorrhage

Dosage will be 1 gram, 3 times daily. Drug dosing will be initiated at time of aSAH confirmation, for a length of 14 days or at hospital discharge.

Tiopronin

Placebo

The Columbia University Medical Center Department of Neurosurgery Website

The University of Florida Department of Neurosurgery Website

The University of Washington Department of Neurosurgery Website

Principle Investigator: E. Sander Connolly Jr.

Connolly Cerebrovascular Research Laboratory

University of Florida

Columbia University Medical Center

University of Washington

The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage

Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage

CSF samples taken as a standard of care at each institution will be tested for routine parameters. A small portion of this sample will be saved and sent to Columbia University Medical Center to measure 3AP levels.

Outcome assessments will include:
Modified Rankin Scale
Barthel Index
Lawton Physical Self Assessment Test (PSMS)
Lawton Instrumental Activities of Daily Living (IADL)
NIH Stroke Scale (NIHSS)
Telephone Interview Cognitive Status (TICS)

polyamine/asiņošana

Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Use of Mesenchymal Stem Cells in Inflammatory Bowel Disease

The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage

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