A lubricant composition with a total nitrogen content of 0.1 to 0.25 percent by weight suitable for lubricating a two-stroke engine comprising an oil of lubricating viscosity, a synthetic ester, at least one condensation product of a fatty acid having 12 to 24 carbon atoms with a polyamine, and a Mannich dispersant.

The Lubrizol Corporation

Lubricant additive composition suitable for lubricating, preventing deposit formation, or clean-up of two-stroke engines

The present invention provides a diagnostic method for stroke/asymptomatic cerebral infarction and a screening method for patients with stroke/asymptomatic cerebral infarction, which comprise measuring acrolein content or polyamine content; or polyamine oxidase activity or protein content of polyamine oxidase in plasma. The knowledge of the present invention indicates the possibility of preventing, inhibiting the progression of stroke/asymptomatic cerebral infarction by inhibiting polyamine oxidase, and the possibility of obtaining a therapeutic agent for stroke/asymptomatic cerebral infarction by searching for compounds that inhibit polyamine oxidase.

Igarashi; Kazuei

Ueda; Shiro

Saeki; Naokatsu

Kashiwagi; Keiko

Tomitori; Hideyuki

Method of diagnosing apoplectic stroke/asymptomatic brain infarction using acrolein content

Polyamine compounds, method of synthesis and method of use for anti-cancer purposes, for enhancing the activity of existing anti-cancer drugs, as well as, for inhibiting N-Methyl-D-Aspartate (NMDA) receptors found in neurotransmission systems are provided. Certain polyamine motifs have been identified that can be attached to toxic agents to facilitate their access to cancer cells as well as polyamine compounds of surprising cytotoxicity with selectivity in killing cancer cells, and surprising utility in the treatment of Alzheimer's disease and brain stroke. It includes an illustrative conjugate system with examples of a triamine or a tetraamine appended to a cytotoxic agent. Included is a general strategy to enhance cell uptake by attaching a polyamine vectoring system with an example of a triamine vector attached to an existing anti-cancer drug to improve its chemotherapeutic potency. There is an illustration of tetraamine derivatives which have surprising enhanced selectivity in inhibiting N-methyl-D-aspartate (NMDA) receptors involved in neurotransmission. Several ligands can affect the activity of this receptor, which has been shown to initiate cell death under stroke conditions (lack of oxygen). Tetraamine derivatives which bind or inhibit the action of the NMDA receptor provide new therapy for NMDA-associated human diseases, such as Alzheimer's disease and stroke.

polyamine/insults

Lubricant additive composition suitable for lubricating, preventing deposit formation, or clean-up of two-stroke engines

Method of diagnosing apoplectic stroke/asymptomatic brain infarction using acrolein content

Polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs

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