spasmogenic/hypersensitivity

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A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids.

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Ielogoties Reģistrēties

The anti-asthmatic activity of AA-2414 [(+/-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptano ic acid] has been studied in vivo and in vitro. Experimental allergic asthma was inhibited by orally administered AA-2414 in a dose-dependent manner. AA-2414, 0.08-1.25 mg/kg (p.o.), inhibited the

Anti-allergy properties of PRD-92 Ea in guinea pig and rat.

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Ielogoties Reģistrēties

The effects of PRD-92 Ea were examined on the increased plasma protein extravasation in the skin of guinea pig and rat elicited by specific antigens and spasmogenic mediators. PRD-92 Ea was found to be a potent inhibitor of rat PCA reactions when administered intradermally, intravenously or orally.

Allergic reactions to indoor air pollutants.

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Ielogoties Reģistrēties

Inhalation of airborne chemicals can result in allergic sensitization with episodic pulmonary responses occurring on subsequent exposures. Responses may occur in the upper respiratory tract (rhinitis), the lower respiratory tract (wheeze, bronchospasm) or systemically, for example, a febrile

ANTIOXIDANT, ANTIBACTERIAL AND GUT MODULATING ACTIVITIES OF KALANCHOE LACINIATA.

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Ielogoties Reģistrēties

Kalanchoe laciniata (L.) DC. (Crassulaceae) is a widely distributed plant in Africa and Asia. Traditionally, various communities use this plant for the treatment of a variety of ailments such as gut prob- lems, allergic conditions and wounds. The current study was designed to explore the

[Ketotifene: experimental and clinical data].

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Ielogoties Reģistrēties

Some important pharmacodynamic and clinical data on ketotifen, a benzocycloheptathiophene used in the prophylaxis of allergic asthma, are provided as an introduction to papers discussing the therapeutic use of this substance in adults and children. Ketotifen, which is active when administered

[Leukotrienes: their significance in the pathogenesis of asthma].

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Ielogoties Reģistrēties

Cysteinyl leukotrienes (cys-LT) are potent spasmogenic agents, increase markedly vascular permeability and mucus secretion and promote intense recruitment, with activation, of inflammatory cells into the airways, increasing bronchial responsiveness. An augmented release of cys-LT from

Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.

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Ielogoties Reģistrēties

The pathochemical mechanisms of bronchospasm have been studied using various type of experimental allergies to microbial antigens. It was established that in guinea pigs with type I allergies isolated lung bronchospasm was mediated by histamine and SRS-A. Bronchial response to immune complexes type

Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma.

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Ielogoties Reģistrēties

Prostacyclin (PGI2) is generated in appreciable amounts during allergic reactions in human lung tissue. To define its activity on human airways we have studied the effects of doubling concentrations of inhaled PGI2 and its hydrolysis product 6-oxoprostaglandin F1 alpha (6-oxo-PGF1 alpha) on specific

Pharmacological comparison of isolated bronchial artery and pulmonary vein: possible functional relationships.

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Ielogoties Reģistrēties

Using selective agonists and antagonists, active alpha and beta 1-adrenoceptors and muscarinic cholinoceptors were identified in isolated strips of bronchial artery and pulmonary vein. Beta 2 receptors were located in the bronchial artery only. The bronchial artery was more sensitive to

Helminth-induced intestinal inflammation.

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Ielogoties Reģistrēties

Gastrointestinal inflammation is a prominent feature of protective reactions in animals immune against helminths. Infiltration into the inflamed mucosa of various cells and their subsequent activation result in the elaboration of an array of pharmacologically and biologically active substances. The

Environmental injury of the lung: role of humoral mediators.

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Ielogoties Reģistrēties

Environmental lung injury may take the form of acute tracheobronchitis, asthma, pulmonary edema, chronic bronchitis, emphysema, allergic pneumonitis, fibrosing alveolitis, pleurisy, and neoplastic disease. Environmental factors eliciting these responses include irritant gases and fumes, oxidants,

[Bronchospasms induced by acetylcholin and free running exercise. A comparison in 50 asthmatic children (author's transl)].

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Ielogoties Reģistrēties

Fifty asthmatic children were tested for cholinergic bronchial sensitivity and subjected to a free running exercise test; 92% of them showed hypersensitivity to acetylcholine challenge, and exercise-induced bronchospasm occurred in 80%. On pooling the results, 98% had a positive response to at least

Antagonism of peptidoleukotrienes and inhibition of systemic anaphylaxis by RG 12525 in guinea pigs.

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Ielogoties Reģistrēties

RG 12525 was determined to be a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, in several assays utilizing guinea pigs. In vitro, RG 12525 competitively inhibited 3H-LTD4 binding to lung membranes (Ki = 3.0 +/- 0.3 nM) and competitively

An unusual case of anaphylaxis. Mold in pancake mix.

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Ielogoties Reģistrēties

Anaphylactic reactions involve contact with an antigen that evokes an immune reaction that is harmful. This type of reaction is a rapidly developing immunologic reaction termed a type I hypersensitivity reaction. The antigen complexes with an IgE antibody that is bound to mast cells and basophils in

Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats.

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Ielogoties Reģistrēties

Rats were fed semi-purified diets supplemented either with safflower seed oil rich in linoleate (18:2n-6) or with perilla seed oil rich in alpha-linolenate (18:3n-3) through two generations. In the major phospholipids of polymorphonuclear leukocytes (PMNs), the proportions of n-6 polyunsaturated

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