sphingomyelin/drudzis

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Malignant hyperthermia: an altered phospholipid and fatty acid composition in muscle membranes.

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Ielogoties Reģistrēties

There is thought to be a genetic defect within the calcium release channel of the sarcoplasmic reticulum in malignant hyperthermia (MH). This primary alteration is hypothesized to influence the function and/or structure of various muscle membrane systems; e.g., to have a direct effect on the

[Change in the lipid composition of rat tissues in hyperthermia of varying degree].

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Ielogoties Reģistrēties

The most typical alteration of membrane phospholipids in rat tissues in acute hyperthermia was an increase in content of sphingomyelin and phosphatidylinositol. The increase in phosphatidylinositol appears to occur as a result of unspecific effect of hyperthermia on the cells, while the increase of

Allometric dependence of the life span of mammal erythrocytes on thermal stability and sphingomyelin content of plasma membranes.

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Ielogoties Reģistrēties

Thermal stability of erythrocyte membrane is a measure for its ability to maintain permeability barrier at deleterious conditions. Hence, it could impact the resistance of erythrocytes against detrimental factors in circulation. In this study the thermostability of erythrocyte membranes was

Mild testicular hyperthermia transiently increases lipid droplet accumulation and modifies sphingolipid and glycerophospholipid acyl chains in the rat testis.

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Ielogoties Reģistrēties

Spermatogenesis is known to be vulnerable to temperature. The aim of this study was to investigate the effects on testicular lipids of the transient germ cell loss that is induced by mild testicular hyperthermia. Adult rat testes were exposed once a day to 43 °C for 15 min for 5 days and the effects

Lipid catabolism of relapsing fever borreliae.

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Ielogoties Reģistrēties

Relapsing fever borreliae require lipid compounds for growth in vitro. In this study, the major pathways of lipid catabolism in three species of tick-borne relapsing fever borreliae were investigated. Thin-layer chromatography was used to compare chloroform-methanol extracts of fresh culture media

Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis.

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Ielogoties Reģistrēties

We recently reported that a mild heat shock induces a long lasting stimulation of TRAIL-induced apoptosis of leukemic T-lymphocytes and myeloid cell lines, but not normal T-lymphocytes, which correlates with an enhanced ability of TRAIL to recognize its receptors. As shown here, this phenomenon

[Reye syndrome and drug induced encephalopathy].

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Ielogoties Reģistrēties

Reye syndrome, characterized by acute encephalopathy, selective liver damages, a fatty degeneration in visceral organs and miserable prognosis, is probably caused by various drugs, especially antipyretic such as acetylsalicylate. The incidence of the disease has been decreased by prohibition of

Do chilling injury and heat stress share the same mechanism of injury in oocytes?

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Ielogoties Reģistrēties

Chilling injury is the major limiting factor for successful cryopreservation of both human and animal oocytes. Maternal hyperthermia is the main reason for summer infertility in dairy cows. In this paper, we will present evidence for the involvement of membrane lipid composition and its

The role of sphingolipids in the control of skeletal muscle function: a review.

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Ielogoties Reģistrēties

In this review, potential roles for the endogenous sphingolipid, sphingosine, and its derivatives are described for muscle cells. Sphingosine modulates the function of important calcium channels in muscle, including the ryanodine receptor (RyR) calcium release channel of the sarcoplasmic reticulum

Neuronal cell death in alphavirus encephalomyelitis.

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Ielogoties Reģistrēties

Alphaviruses are mosquito-borne, enveloped, plus-strand RNA viruses that cause a spectrum of diseases in humans that include fever, rash, arthritis, meningitis, and encephalomyelitis. Sindbis virus (SINV) is the prototype alphavirus, causes encephalomyelitis in mice, and provides a model system for

Chikungunya virus fusion properties elucidated by single-particle and bulk approaches.

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Ielogoties Reģistrēties

Chikungunya virus (CHIKV) is a rapidly spreading, enveloped alphavirus causing fever, rash and debilitating polyarthritis. No specific treatment or vaccines are available to treat or prevent infection. For the rational design of vaccines and antiviral drugs, it is imperative to understand the

Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses.

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Ielogoties Reģistrēties

Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur Forest disease, tick-borne encephalitis, or Zika disease. This viral genus groups >50 viral species of small enveloped plus

Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency).

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Ielogoties Reģistrēties

OBJECTIVE Enzyme replacement therapy with olipudase alfa (recombinant human acid sphingomyelinase) is being developed for Niemann-Pick disease type B (NPD B). METHODS A single-center, open-label, nonrandomized, single-ascending-dose trial evaluated the safety of intravenous olipudase alfa (0.03-1.0

Plasma lipid profiles discriminate bacterial from viral infection in febrile children.

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Ielogoties Reģistrēties

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the

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