Participants will receive standard care regarding nail toxicity. This entails advice to keep nails trim and the provision of a nail oil to massage into the nail daily. Participants will also receive advice in relation to general healthy living.

Participants will receive the same standard care as the control arm, except for the nail drops. The participants will also receive Onicolife nail drops to be applied twice daily.

Participants will receive the same standard care as the control arm, except for the nail drops. The participants will also receive a dark coloured nail polish to be applied as instructed.

Breast Cancer

Nail Toxicity

The prescription free, CE (Conformité Européenne) marked product is for local application, and has a novel mode of action involving the modulation of mast cell action with the fatty acid amide, Adelmidrol ®. Mast cells are known to have a key role in the ability of the body to promote healing /repair and control tissue damage caused by chemo and radiotherapy. This includes damage to the nail and/ or nail matrix. OnicoLife ® thus helps to control inflammation and pain whilst antimicrobial action also provides antibacterial and antifungal support.

Onicolife nail drops

One dark colour of nail polish (deep burgundy/red) will be used in this study since this colour is considered more acceptable to many more women than a pure black coloured nail polish and hence, more likely to ensure compliance. No nail polish containing hardeners will be used since there is some evidence to suggest they can induce nail changes. As dark nail polish can stain the nail plate (and therefore mask any changes in nail pigmentation induced by chemotherapy), one clear base coat, two coats of coloured, and one clear top coat of polish will be required for each application. This standard of application is proposed as a gold standard for the prevention of nail staining and hypersensitivity reactions by an eminent podiatrist (Spalding, 2008).

Nail polish

Beatson Oncology Centre

Taxane Chemotherapy and Nail Toxicity in Women With Breast Cancer; Stage Two: Evaluation of Interventions

Evaluate nail interventions (nail polish + standard care Vs Onicolife drops + standard care Vs Standard Care only) that may prevent or minimise the occurrence and severity of nail problems measured using the NToX-G12 (Nail Assessment Scale).

Evaluate nail interventions (nail polish + standard care Vs Onicolife drops + standard care Vs Standard Care only) that may prevent or minimise the occurrence and severity of nail problems measured using Common Terminology Criteria for Adverse Events v3.0 (CTC-AE v3).

Evaluate any change in the patient's quality of life, in relation to nail problems occurring, as measured using the NToX-QoL (quality of life questionnaire).

Evaluate any change in the patient's quality of life, in relation to nail problems occurring, as measured using the EQ-5D-5L (quality of life questionnaire)

Assess collected data for any correlating relationship between nail grade severity (measured using NToX-G12 - outcome measure 1) and qualify of life (measured using NToX-QoL - outcome measure 3).

NHS Greater Glasgow and Clyde

RayGel Topical Cream applied in thin layer to the area exposed to radiation 60-90 minutes prior to radiotherapy, standard skin care between treatments.

Placebo Topical Cream applied in thin layer to the area exposed to radiation 60-90 minutes prior to radiotherapy, standard skin care between treatments.

Reduced glutathione

Legacy Health System

RayGel-An Alternative for Skin Care During External Beam Radiation

Prospective Blinded Randomized Study; RayGel Versus Placebo-an Alternative for Skin Care During External Beam Radiation.

Skin reaction scale along with evaluation by radiation oncologist at weekly intervals from start of radiation therapy until completion of radiation.

Nathalie Johnson

Principal investigator

Advanced Non-Small Cell Lung Cancer

Carboplatin

Paclitaxel

Gene expression profiling (analysis) of tumor samples

University of Michigan Comprehensive Cancer Center

Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC Through Gene Expression Profiling

Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced Non-Small Cell Lung Cancer Through Gene Expression Profiling.

University of Michigan Rogel Cancer Center

Phase II Evaluation of Carboplatin, Pacitaxel, and Bevacizumab as First Line Chemotherapy and Consolidation for Advanced Ovarian Cancer.

Phase II of Carboplatin, Pacitaxel, and Bevacizumab

Sex: Female, Male

Region of Enrollment

Progression Free Survival: To examine the toxicity, estimate the objective response rate, and progression free survival measured in months of carboplatin, paclitaxel, and bevacizumab followed by single agent bevacizumab as consolidation for advanced mullerian cancer

To estimate the objective response rate of carboplatin, paclitaxel, and bevacizumab. Evaluate toxicity.

Response Rate (RECIST-1)

Per CTCAE (Common Toxicity Criteria for Adverse Events) number of participants who experienced toxicity on the study

taxol/asiņošana

Taxane Chemotherapy and Nail Toxicity in Women With Breast Cancer; Stage Two: Evaluation of Interventions

RayGel-An Alternative for Skin Care During External Beam Radiation

Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC Through Gene Expression Profiling

Carboplatin Taxol Avastin in Ovarian Cancer (OVCA)

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