taxus mairei/paclitaxel

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An endophytic fungus efficiently producing paclitaxel isolated from Taxus wallichiana var. mairei.

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Ielogoties Reģistrēties

Paclitaxel is a medicinal ingredient with high anticancer activity and widely used in hospitals and clinics. In this study, we isolate endophytic fungi efficiently producing paclitaxel from yew for the purpose of paclitaxel manufacture.The bark of Taxus wallichiana var. mairei was surface sterilized

ISOLATION AND IDENTIFICATION OF AN ENDOPHYTIC FUNGUS PRODUCING PACLITAXEL FROM TAXUS WALLICHIANA VAR MAIREI.

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Ielogoties Reģistrēties

The objective of this study was to isolate endophytic fungi producing paclitaxel from yew for the purpose of paclitaxel manufacture. Surface sterilized bark of Taxus wallichiana var. mairei was used as source material and potato dextrose agar culture medium was used in isolation of endophytic fungi.

Distribution of paclitaxel and its congeners in Taxus mairei.

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Ielogoties Reģistrēties

Concentrations of paclitaxel and its congeners 10-deacetylpaclitaxel, cephalomannine, 10-deacetylcephalomannine, baccatin III and 10-deacetylbaccatin III in Taxus mairei were determined by HPLC. It was found that paclitaxel is abundant in roots and stem bark. The concentrations of paclitaxel and its

Comparative proteomic analyses of two Taxus species (Taxus × media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites.

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Ielogoties Reģistrēties

Taxus species are well-known for paclitaxel, which exhibits antitumor activities and is used for treating various cancers. Although most Taxus species are widespread in many areas, few studies have characterized the variation in metabolism among different Taxus species. Using an integrated approach

Isolation of an endophytic fungus producing baccatin III from Taxus wallichiana var. mairei.

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Ielogoties Reģistrēties

The objective of this study was to isolate endophytic fungi producing baccatin III from yew for the purpose of baccatin III and paclitaxel manufacture. Surface sterilized bark of Taxus wallichiana var. mairei was used as source material with potato dextrose agar culture medium for isolation of

1-deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei.

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Ielogoties Reģistrēties

A new paclitaxel derivative and two new 2(3-->20)-abeo-taxoids were isolated from a methanol extract of the seeds of Taxus mairei, and their structures were established as 1-deoxypaclitaxel (1), 7beta,10beta-diacetoxy-2alpha,5alpha,13alpha-trihydroxy-2(3-->20)-abeo-taxa-4(20),11-dien-9-one (2), and

[Analysis and evaluation of taxol contents in different parts between Taxus media and Taxus mairei based on Fourier transform infrared spectroscopy].

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Ielogoties Reģistrēties

In the present study, combined with external standard method, second derivative as well as curve-fitting equation, the infrared spectroscopy techniques were applied to research the discrepancy of paclitaxel content among different parts of them repectively as well as the differences of infrared

Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei).

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Ielogoties Reģistrēties

Taxol is currently a valuable anticancer drug; however, the accumulated mixture of taxoids can vary greatly among Taxus species. So far, there is very little genomic information for the genus Taxus, except for Taxus baccata. Transcriptome analysis is a powerful approach to explore the different

Seasonal Dynamics of Metabolites in Needles of Taxus wallichiana var. mairei.

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Ielogoties Reģistrēties

Seasonal variations of the phytochemicals contents in needles of T. wallichiana var. mairei due to the effects of growth meteorological parameters were investigated in this study. The needles of T. wallichiana var. mairei were collected from different months and the contents of taxoids (paclitaxel,

Synthesis, biological activity and tubulin binding poses of 1-deoxy-9-(R)-dihydrotaxane analogs.

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Ielogoties Reģistrēties

1-Deoxy-9alpha-dihydrotaxane analogs 9 and 10 were semi-synthesized from 1-deoxybaccatin VI, isolated from Taxus mairei, and tested for cytotoxic activity. Taxane 9 is 10-fold less cytotoxic than paclitaxel, while 10 is equally active. In the tubulin polymerization assay (ED(50) values), 10 is

Semi-synthesis of 1-deoxypaclitaxel and its analogues from 1-deoxybaccatin VI.

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Ielogoties Reģistrēties

Despite numerous synthetic efforts and extensive SAR studies on paclitaxel analogs, little work has been devoted to derive SAR of the C-1 hydroxy group. Up to now, 1-deoxypaclitaxel has only been reported to be isolated from the Chinese yew, Taxus mairei (Taxaceae). However, the isolation from

Bacterial diversity of Taxus rhizosphere: culture-independent and culture-dependent approaches.

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Ielogoties Reģistrēties

The regional variability of Taxus rhizosphere bacterial community composition and diversity was studied by comparative analysis of three large 16S rRNA gene clone libraries from the Taxus rhizosphere in different regions of China (subtropical and temperate regions). One hundred and forty-six clones

Identification of Taxus microRNAs and their targets with high-throughput sequencing and degradome analysis.

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Ielogoties Reģistrēties

Plant microRNAs (miRNAs) have an impact in the regulation of several biological processes such as development, growth and metabolism by negatively controlling gene expression at the post-transcriptional level. However, the role of these small molecules in the medicinal gymnosperm species Taxus

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