zymogen/hypoxia

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Cyclosporin a, but not FK506, induces osmotic lysis of pancreas zymogen granules, intra-acinar enzyme release, and lysosome instability by activating K+ channel.

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OBJECTIVE The immunosuppressant tacrolimus (FK506) has improved pancreas allograft survival compared with cyclosporin A (CsA), possibly because of reduced acute pancreatitis following ischemia-reperfusion injury. Ion permeabilities in zymogen granule (ZG) membranes, including a KCNQ1 K channel,

Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia.

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OBJECTIVE Pigment epithelium-derived factor (PEDF), a protein secreted by the retinal pigment epithelium (RPE), acts on retinal survival and angiogenesis. Because hypoxia and VEGF regulate matrix metalloproteinases (MMPs), their effects on PEDF proteolysis were explored. METHODS Mouse models for

Safer surgery using zymogen protein C concentrate.

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This is the first case (November 12, 2007) of peri-operative use of zymogen protein C (ZPC) for a heterozygote Protein C deficient (50%) patient with heterozygosity for the prothrombin gene mutation. The surgery involved total left hip replacement. The patient was 74 years of age and at very

Matrix Metalloproteinase 13 Activity is Required for Normal and Hypoxia-Induced Precocious Hatching in Zebrafish Embryos.

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Hypoxia induces precocious hatching in zebrafish, but we do not have a clear understanding of the molecular mechanisms regulating the activation of the hatching enzyme or how these mechanisms trigger precocious hatching under unfavorable environmental conditions. Using immunohistochemistry,

[Ultrastructural changes in the acinar cells of the pancreas after exposure to cold].

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Electron microscopy of acinar cell (AC) of the pancreas cooled to -30 degrees C with subsequent thawing has disclosed the destruction of intracellular membranes, damage to the cell organelles followed by diffusion of the zymogen granule contents to the hyaloplasm and interstice. These changes

Ultrastructural changes of the human pancreas in acute shock.

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Human pancreas tissue was studied electron microscopically during various stages of shock. The subcellular changes of exocrine pancreas affect in particular endoplasmic reticulum (ER), mitochondria, cytoplasm, and nuclei. Alterations correlate with duration and severity of shock, causing cell death

[The role of the myocardial depressant factor in the pathogenesis of the shock].

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Examination of the pathogenesis of shock has directed attention to the microcirculation, the kidneys, and the lungs. Today, apart from other tissues and organs, particularly the splanchnic organs, the pancreas is also incriminated. The lysosomes (also present in other tissues) and zymogen granules

Tissue-type plasminogen activator has a neuroprotective effect in the ischemic brain mediated by neuronal TNF-α.

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Cerebral cortical neurons have a heightened sensitivity to hypoxia and their survival depends on their ability to accommodate to changes in the concentration of oxygen in their environment. Tissue-type plasminogen activator (tPA) is a serine proteinase that activates the zymogen plasminogen into

Hyperbaric Oxygen Therapy Accelerates Wound Healing in Diabetic Mice by Decreasing Active Matrix Metalloproteinase-9.

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Diabetic foot ulcers are characterized by hypoxia. For many patients, hyperbaric oxygen (HBO) therapy is the last recourse for saving the limb from amputation, for which the molecular basis is not understood. We previously identified the active form of matrix metalloproteinase-9 (MMP-9) as

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