Bioavailability of Xanthones From Mangosteen
Клучни зборови
Апстракт
Опис
Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The pericarp of mangosteen fruit is used in traditional medicine to treat inflammation, infections, wounds, and diarrhea. The proposed health-promoting effects have been attributed to a family of polyphenols referred to as xanthones. Since its introduction into the United States, juices and products containing mangosteen fruit have become a top-selling botanical dietary supplement. This commercial success largely has been the result of aggressive marketing of health claims based on in vitro observations and anecdotal reports.
The purpose of this study was to determine the bioavailability of xanthones from mangosteen juice in adult human subjects. After an overnight fast of at least 10h, male and female subjects were admitted to the Ohio State University Clinical Research Center. Volunteers ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and 1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit after the 8h collection, refraining from mangosteen containing products until final collection of blood at 24h. Urine was collected for the 24 test period.
Датуми
| Последен пат проверено: | 07/31/2011 |
| Прво доставено: | 08/25/2011 |
| Поднесено е проценето запишување: | 08/25/2011 |
| Прво објавено: | 08/28/2011 |
| Последното ажурирање е доставено: | 08/30/2011 |
| Последно ажурирање објавено: | 09/01/2011 |
| Крај на датумот на започнување на студијата: | 10/31/2010 |
| Проценет датум на примарно завршување: | 10/31/2010 |
| Проценет датум на завршување на студијата: | 01/31/2011 |
Состојба или болест
Фаза
Групи за раце
| Рака | Интервенција / третман |
|---|---|
| Females ingesting mangosteen juice | |
| Males ingesting mangosteen juice |
Критериуми за подобност
| Возраст подобни за студии | 18 Years До 18 Years |
| Полови квалификувани за студии | All |
| Метод на земање примероци | Non-Probability Sample |
| Прифаќа здрави волонтери | Да |
| Критериуми | Inclusion Criteria: - 5 female - 5 male - body mass index - normal renal function - non-smoking Exclusion Criteria: - smokers - acute or chronic diseases - history of gastrointestinal diseases - >/= 10% weight loss - dietary or herbal supplement within 6 months of study - pregnancy |
Исход
Мерки на примарниот исход
1. Xanthones in urine [0-24 hours]
Секундарни мерки на исходот
1. Xanthones in sera [0-24 hours]
